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Şimşek, Fatma
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Neuroscience

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THE RELATIONSHIP BETWEEN CEREBROSPINAL FLUID PRESSURE AND ATHEROGENIC INDEX OF PLASMA IN IDIOPATIC INTRACRANIAL HYPERTENSION PATIENTS Şimşek, Fatma; Yevgi, Recep; Dağcı, Yıldız
MNJ (Malang Neurology Journal) Vol. 8 No. 1 (2022): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.01.3

Abstract

Background: Idiopathic intracranial hypertension (IIH) is a disease thought to be associated with obesity and rapid weight gain. There is no objective parameter with practical use in its follow-up and treatment other than optical coherence tomography.Objective: The aim of our study is to investigate the relationship between atherogenic index of plasma (AIP) and cerebrospinal fluid (CSF) pressure.Methods: Serum vitamin B12, vitamin D, homocysteine, folic acid, triglyceride (TG), high density lipoprotein cholesterol (HDL-C) levels, CSF pressure, CSF microprotein levels were recorded from the file data of patients diagnosed with IIH. AIP was calculated by dividing the TG level logarithmically by HDL-C. Height (kg) and weight (kg) data of the patients were used to calculate the body mass index (BMI).Results: File data of 64 patients were examined. 8 patients with secondary intracranial hypertension were excluded from the study. 80.36% of the patients were overweight, 16.07% were obese, 3.57% were with normal weight. There was no significant correlation between vitamin B12, vitamin D, homocysteine, HDL-C and CSF microprotein levels and CSF pressure level in patients with a diagnosis of IIH. There was a negative correlation between folic acid level and CSF pressure level, and a positive correlation between BMI, TG, AIP and CSF pressure level.Conclusion: Using folic acid supplements and drugs that reduce TG levels can contribute positively to the course of the disease.
THYMOMA REMISSION WITH STEROID THERAPY IN MYASTHENIA GRAVES WITH GIANT THYMOMA Şimşek, Fatma
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.17

Abstract

The thymoma is an uncommon neoplasm. It is detected incidentally in some patients. Myasthenia gravis (MG) is an autoimmune disease and closely related to thymoma. Between 10% and 20% of patients with MG have thymoma and 30%–50% of patients with thymoma have MG. Thymectomy is part of the treatment for MG patients. However, the patient must be stabilized before thymectomy. We present a 26-year-old male case with giant thymoma. In the initial evaluation of the patient, a giant-sized thymoma was observed, which was thought to cause vascular invasion.  Interestingly, the introduction of corticosteroid therapy for MG symptom management resulted in unexpected significant remission of giant thymoma. After steroid treatment, thymectomy was performed. This case demonstrated that steroid therapy was effective and well tolerated for the treatment of both thymoma and MG. Therefore, steroid therapy should be continued for a while for thymoma remission before surgery in MG patients with giant thymoma. Treatment is arranged according to the clinical findings of the patient. Each patient's response to treatment and duration of treatment may differ from each other.   After thymectomy, long-term follow-up is required for the possibility of thymoma becoming malignant.
THE ASSESSMENT OF SERUM ADROPIN AND CATALASE LEVELS IN PATIENTS WITH ALZHEIMER'S DISEASE: ADROPIN AND CATALASE LEVELS IN PATIENTS WITH ALZHEIMER'S DISEASE Şimşek, Fatma; Aktaş, Yunus Emre; Gündoğdu, Ömer Lütfi; Kızıltunç, Ahmet
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.07

Abstract

Background: Dementia is a disease that renders performing activities of daily living difficult and has a high cost of treatment. Objective: In this context, this study was conducted to assess the adropin and catalase levels, the relationship between adropin and catalase levels, and the roles of adropin and catalase in treatment in patients diagnosed with Alzheimer's type dementia. Methods: This observational analytical study's sample consisted of 30 patients with Alzheimer’s disease (AD). Thirty individuals without dementia whose age and gender characteristics matched those with AD were included in the control group. The adropin and catalase levels in the serum samples collected from both patient and control groups were analyzed. Results: Adropin and low-density lipoprotein cholesterol (LDLC) levels were notably elevated in patients with Alzheimer's disease (AD). In contrast, levels of vitamin D, albumin, and catalase were significantly reduced in these patients. Additionally, there was no meaningful correlation between the mini-mental state examination (MMSE) scores and the results of laboratory tests in individuals with AD. Additionally, it was determined that MMSE scores were positively correlated with adropin levels and negatively correlated with catalase levels. However, both correlations were statistically insignificant. Conclusion: The low levels of catalase in patients with AD support the important role of oxidative stress in the disease. The high levels of adropin in these patients suggest that adropin acts as a defense mechanism for the body. Catalase and adropin can be used as biomarkers in the diagnosis of AD, but they are not suitable biomarkers for assessing cognitive functions.
Co-Authors Aktaş, Yunus Emre Dağcı, Yıldız Gündoğdu, Ömer Lütfi Kızıltunç, Ahmet Yevgi, Recep