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All Journal Journal of Scientific Research, Education, and Technology Vitamedica: Jurnal Rumpun Kesehatan Umum The Journal General Health and Pharmaceutical Sciences Research Inovasi Kesehatan Global
Siti Mudrikatin
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Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The Effectiveness of Red Ginger To First Trimester In Pregnant Women With Emesis Gravidarum Siti Mudrikatin
VitaMedica : Jurnal Rumpun Kesehatan Umum Vol. 2 No. 3 (2024): Juli : VitaMedica : Jurnal Rumpun Kesehatan Umum
Publisher : STIKES Columbia Asia Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62027/vitamedica.v2i3.106

Abstract

Nausea and vomiting or emesis gravidarum are symptoms that commonly occur in pregnant women in the firs trimester and are physiological, caused by hormonal changes in pregnant women. The purpose of this study was to determine the effectiveness of giving red ginger water to reduce the frequency of emesis gravidarum in first trimester pregnant women. One Group Pre-Post Test Design research design. The research was conducted in Februari - July 2024 in the working area of the Jabon Public Health Center Jombang. The sample was 60 respondents selected with purposive sampling technique. The instrument used to measure emesis gravidarum is The Rhodes Index Nausea, Vomiting and Retching. Bivariate analysis using the Mann-Whitney test. The average difference in the frequency of emesis gravidarum before and after the intervention of red ginger extract was 3.01 and cardamom water was 2.91. The results of the Mann-Whitney test in which the intervention pretest and posttest intervention pairs of giving red ginger were a p value of 0.000 <0.05. Giving red ginger intervention is effective in reducing the nausea of emesis gravidarum significantly in reducing the frequency of emesis gravidarum.
Prevention Efforts of Covid-19 Qualitative Study Transmission in East Java Province Siti Mudrikatin
Journal of Scientific Research, Education, and Technology (JSRET) Vol. 3 No. 1 (2024): Vol. 3 No. 1 2024
Publisher : Kirana Publisher (KNPub)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58526/jsret.v3i1.320

Abstract

East Java has seen a steady increase in COVID-19 cases, with 1,221 people affected and 3547 lives lost. The study used in-depth interviews with stakeholders supported by NGOs and the Integrated Command Post to understand the phenomenon. The sample included nine cities in East Java Province, including Surabaya, Malang, Kediri, Batu, Blitar, Madiun, Mojokerto, Pasempuan, and Probalingga. The results of these interviews were disseminated to health workers in East Java using the Question-and-Answer lecture method. The health department and stakeholders at the Integrated Command Post collaborated to socialize technical guidelines for preventing COVID-19 transmission. The material presented in the program policies aims to prevent COVID-19 transmission in East Java. Stakeholders' policies towards the Integrated Command Post capacity building program are crucial for preventing COVID-19 transmission. Regulations or laws are necessary to regulate efforts in East Java. Monitoring and evaluation are carried out by stakeholders at the integrated post in East Java, with the health department monitoring its evaluation through monthly reports sent through puskesmas and hospitals based on the COVID-19 examination laboratory network. The study aims to provide information on self-isolation and increase support and cooperation across sectors and local governments in handling COVID-19.
Menjelajahi Sifat Antiinflamasi dan Antioksidan Jahe Merah pada Pencegahan Terjadinya Polikistik Ovarium Syndrome (PCOS): Studi In Silico dan In Vivo Siti Mudrikatin; Herin Herin
The Journal General Health and Pharmaceutical Sciences Research Vol. 3 No. 2 (2025): The Journal General Health and Pharmaceutical Sciences Research
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/tjghpsr.v3i2.770

Abstract

Background of the incident of increasing cases of polycystic ovary syndrome (PCOS) with a prevalence of insulin resistance of 50-75%, insulin resistance will cause oxidative stress due to hyperglycemia which will then increase proinflammatory cytokines in TNF-α and other cytokines, thus triggering an increase in inflammation resulting in an increase in infertility cases of 89.6%. The aim is to investigate the prevention of PCOS through red ginger injected with testosterone propionate in vivo, insilico using open babel software on PyRx V.1.0. The in vivo method is an experimental laboratory study, using two five rats of the rattus norvegicus type divided into five groups using PCOS prevention through red ginger, examinations carried out on blood and ovarian organs, preparations were made which were observed with a binocular microscope on TNF-a examination with immunohistochemistry, ELISA examination on insulin levels, blood examination on blood glucose, data analysis was carried out using one way ANOVA. The study began with the preparation of control activator ligands, 6-Shogaol (Pubchem ID 5281794) and 6-Gingerol (Pubchem ID 442793) and target receptors TNF-α (PDB ID: 2AZ5) and KEAP1-NRF2 (PDB ID: 5CGJ), Insilico results that occur in red ginger are able to interact at a similar position in the interaction of TNF-α with control compared to KEAP1. In vivo research results showed that testosterone propionate 100 mg / kg BW significantly increased the inflammatory cytokine TNF-α, along with polycystic markers in folliculogenesis (p <0.05) compared to negative controls and administration of red ginger at 800 mg / kg significantly decreased TNF-α levels. red ginger also prevents the occurrence of pcos. The conclusion shows that the bioactive 6-shogaol 6-gingerol in red ginger can provide preventive benefits in polycystic ovary syndrome (pcos) by modulating the inflammatory pathway.
Potensi Ekstrak Etanol (96%) Jahe Merah (Zingiber Officinale Var. Rubrum) dalam Memperbaiki Fungsi Hormon, Ovarium dan Resistensi Insulin pada Tikus Wistar Model Polycystic Ovarian Syndrome Siti Mudrikatin; Edy Anas Ahmadi
Inovasi Kesehatan Global Vol. 1 No. 4 (2024): November: Inovasi Kesehatan Global
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/ikg.v1i4.967

Abstract

Previous studies have shown that red ginger has the potential to treat PCOS because it has been proven to be able to reduce serum FSH, LH and estradiol and testosterone, inhibit the cyclooxygenase pathway, change the pituitary axis, inhibit lipoxygenase expression in various animal studies. The purpose of this study is to prove the potential of red ginger extract as a regulator of anti-androgenic, ovulation, estrogenic activity and reduce insulin resistance. The research design used was for experimental research using a post-test-only control group design. And for the analysis of the potential bioactivity of red ginger extract as an immunomodulatory agent computationally (Insilico). Animal care was carried out in the Pharmacology and Biomedicine Laboratory and has received approval from the Ethics Committee. The sample used was a female Wistar rat on the 56th day of the experiment (after modeling). All treatments were given orally for 28 times. Independent variable = Red ginger extract. Dependent variable = Dependent variables are 1. Hormones: Testosterone, LH, FSH 2. ovarian inflammation activation (PPARγ activation and anti-inflammatory cytokines IL-4 and ROS, NFKB, TNF a. 3. Insulin resistance (insulin, glucose, HOMA IR) and 4 Lipid profile (TG, HDL, LDL, cholesterol). Control variables are: 1) Gender; 2) Age; 3) Strain; 4) Food and beverage intake; 5) Maintenance and care. Quantitative and qualitative research data. using parametric tests, namely One-Way ANOVA after meeting the requirements for normal data distribution and the same data variance. The One-Way ANOVA statistical test is continued with the Tuckey test to determine the differences in each group.
Co-Authors Edy Anas Ahmadi Herin Herin