Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Sriwijaya Journal of Otorhinolaryngology
Lee, Martin Curtis
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Molecular Biomarkers as Predictors of Treatment Response and Survival Outcomes in Head and Neck Squamous Cell Carcinoma: A Retrospective Cohort Study at a Singapore Tertiary Hospital Lee, Martin Curtis; Nazilah Amir
Sriwijaya Journal of Otorhinolaryngology Vol. 2 No. 2 (2024): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v2i1.151

Abstract

Introduction: Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease with variable treatment responses. Identification of molecular biomarkers could personalize treatment and improve outcomes. Methods: A retrospective cohort study was conducted at a tertiary hospital in Singapore. Patients with HNSCC treated between 2018-2023 were included. Pretreatment tumor biopsies were analyzed for biomarker expression (PD-L1, EGFR, TP53, HPV status) using immunohistochemistry and PCR. Clinical data were collected from medical records. Treatment response, survival, and associations with biomarkers were analyzed. Results: 250 patients were included. PD-L1 expression was associated with improved response to immunotherapy (p = 0.02). EGFR overexpression correlated with worse overall survival (p = 0.01). TP53 mutations were linked to increased locoregional recurrence (p = 0.03). HPV-positive tumors had a better prognosis (p < 0.001). Conclusion: Molecular biomarkers show promise in predicting treatment response and survival in HNSCC. Integration of these markers into clinical practice could facilitate personalized treatment strategies.
Co-Authors Nazilah Amir