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All Journal Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Indonesian Journal of Pharmacology and Therapy
Damis, Nur Lutfiah
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Immunology & microbiology Medicine & Pharmacology

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POTENSI EKSTRAK ETIL ASETAT DAUN KELUBUT DARI KOTA SAMARINDA SEBAGAI AGEN ANTIHIPERGLIKEMIK Varizza, Fathiah Putri; Mochtar, Chaerul Fadly; Damis, Nur Lutfiah; Elva; Devi, Reni Selviana; Aisyiyah, Novia Misnawati; Husna, Qur’anni Akhwatun; Faradillah, Ayu
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 10 No. 2 (2023)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v10i2.11334

Abstract

Daun kelubut (Passiflora foetida L.) merupakan bahan alam yang dapat digunakan sebagai pengobatan herbal penyakit diabetes melitus. Penelitian ini bertujuan untuk mengetahui potensi ekstrak etil asetat daun kelubut sebagai antihiperglikemia. Digunakan rancangan the pre-posttest control group design dengan 5 kelompok perlakuan (P1: Na-CMC 1% (kontrol negatif), P2: glibenklamid (kontrol positif), P3: ekstrak etil asetat daun kelubut 250mg/kgBB, P4: ekstrak etil asetat daun kelubut 500mg/kgBB dan P5: ekstrak etil asetat daun kelubut 750mg/kgBB). Sebelum pengujian, mencit diinduksi aloksan dengan dosis 150mg/kgBB secara intraperitoneal. Mencit dengan kadar glukosa >200 mg/dL dapat diberikan perlakuan selama 6 jam secara oral. Pengukuran kadar glukosa dilakukan pada jam ke-0, 3, 4 dan 6. Data yang didapatkan lalu dianalisis menggunakan SPSS versi 26 dengan uji ANOVA. Hasil penelitian menunjukkan bahwa kelompok uji ekstrak etil asetat dengan dosis 750mg/kgBB memiliki kemampuan dalam menurunkan kadar glukosa darah terbaik karena mendekati hasil dari kontrol positif glibenklamid sebagai pembanding. Perbedaan dosis juga mempengaruhi kadar glukosa darah, semakin tinggi dosis yang diberikan, maka efektivitasnya semakin meningkat.
Topical gel preparation from Staphylococcus epidermidis isolate extract accelerated healing on incision wound model in rats Mochtar, Chaerul Fadly; Bakhtiar, Muh Irham; Hamzah, Hasyrul; Pratama, Aldo; Rasyidah, Jamiatur; Indriyani, Juniar Rakhmatia; Alfiannur, Muhammad Rizky; Amalia, Nadhifah Suci; Putri, Nur Octaviany; Damis, Nur Lutfiah
Indonesian Journal of Pharmacology and Therapy Vol 5 No 1 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.11510

Abstract

A wound is a disorder of skin integrity caused by physical trauma or disease. Wound healing is a natural restorative response to tissue injury. It is a complex dynamic physiological process involving several overlapping phases. Although wound management has been applied, however, some time it is associated withmajor drawbak including invasiveness, antibiotic resistance, and high costs. Natural medicines are being developed for wound management to resolve the drawback. Commensal Staphylococcus epidermidis was proven to play a role in natural wound healing process. This study aimed to investigate the wound healingactivity of a topical gel preparation containing S. epidermidis isolate extract on an incision wound model in rats. The methanol extract of S. epidermidis isolate was prepared by maceration and used as an active ingredient of the topical gel using NaCMC as a gelling agent. A physical stability test was carried out by assessingorganoleptic properties, pH value, homogeneity, dispersion, and viscosity of the gel preparation. The gel preparation was then topically applied once-daily for 11 d on incision wound model of male white rats (Rattus norvegicus). The wound healing was observed daily and calculated using Morton’s formula. Nosignificant change in the physical stability parameters of the gel preparation was observed during observation on day 1, 7, and 14 (p>0.05). A significant increase in wound healing after the application of the gel preparation compared to negative control was observed (p<0.05). In contrast, no significant difference inwound healing between the gel preparation and the positive control group was observed (p>0.05). In conclusion, the topical gel preparation from S. epidermidis isolate extract accelerates healing on incision wound models in rats.
Co-Authors Aisyiyah, Novia Misnawati Alfiannur, Muhammad Rizky Amalia, Nadhifah Suci Chaerul Fadly Mochtar Devi, Reni Selviana Elva Faradillah, Ayu Hamzah, Hasyrul Husna, Qur’anni Akhwatun Indriyani, Juniar Rakhmatia Muh Irham Bakhtiar Pratama, Aldo Putri, Nur Octaviany Rasyidah, Jamiatur Varizza, Fathiah Putri