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Kurniawati Y
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Comorbidities in Psoriasis: A Narrative Literature Review N, Nursyarifah; Nopriyati N; Thaha A; Diba S; Kartowigno S; Kurniawati Y
Jurnal RSMH Palembang Vol. 4 No. 2 (2023): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/jrp.v4i2.50

Abstract

Comorbidities in Psoriasis: A Narrative Literature Review. Psoriasis is a chronic inflammatory disease with multisystemic morbidities. The most common comorbidities of psoriasis include psoriatic arthritis, cardiovascular disease, metabolic syndrome, overweight/obesity, inflammatory bowel disease, and mental disturbance in terms of depression. Evidence shows an association of psoriasis with comorbid diseases and have been proposed as related to the chronic inflammatory status of psoriasis. The presence of such comorbidities affects the therapeutic choices for clinicians in comprehensive way. The understanding of these pathogenesis relation and regular screening for early diagnosis of the comorbid diseases will certainly lead to better management of the disease. This is because the management paradigm of psoriasis does not only target repair of skin lesions but also works together with other scientific disciplines to prevent and treat comorbid diseases holistically. Patient often visit the clinician regularly and it is important to recognize and address early signs of psoriatic comorbidities to prevent further deterioration and improve quality of life. The purpose of this review is to summarized pathogenesis and screening recommendation of comorbidity associated with psoriasis, which may be essential for future clinician guideline in order to achieve holistic therapy of psoriasis and quality of life improvement.
Impact of Particulate Matter 2.5 in Acne Vulgaris: A Literature Review Afren I; Kurniawati Y; Diba S; Aryani IA; Argentina F
Jurnal RSMH Palembang Vol. 5 No. 1 (2024): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/jrp.v5i1.62

Abstract

Air pollution is the contamination of any chemical, physical or biological agent that alters the characteristics of the atmosphere. The main environmental pollutants consist of nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO), heavy metals, particulate matter (PM)10 and PM2.5. Particulate matter is a heterogeneous mixture of small particles and liquids consisting of organic chemicals, acids, metals, soil or dust particles. Hair has a diameter of 50-70 µm, while PM10 is 2.5-10 µm and PM2.5 is < 2.5 µm. Air pollution can induce or aggravate skin diseases including acne vulgaris. Particulate matter2.5 triggers skin inflammation and stimulates inflammatory acne lesions through lipid peroxidation and Aryl hydrocarbon receptor (AhR) signaling. Interleukin (IL)-1α and IL-8 are elevated in inflammatory lesions of acne compared to normal skin, showing their role in the exacerbation of acne. The main preventive and therapeutic strategies against air pollution-induced skin damage consist of preventing the penetration of air pollutants through the skin and hair follicles, removing pollutants, improving skin barrier function, increasing skin hydration, and reducing inflammation, as well as preventing collagen and elastin degradation.
Co-Authors Afren I Argentina F Aryani IA Diba S Kartowigno S N, Nursyarifah Nopriyati N Thaha A