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All Journal Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Siregar, Hafiz Syaifullah
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Correlation Between Grade of Non-Alcoholic Fatty Liver Disease and Lipid Profile in Type 2 Diabetes Mellitus Siregar, Hafiz Syaifullah; Brama Ihsan Sazli
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 4 No. 1 (2022): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v4i1.8488

Abstract

Background. Non-alcoholic fatty liver disease (NAFLD) is a form of metabolic liver disease in which fat changes (steatosis) are associated with lobular inflammation, hepatocyte injury, polymorphs, or liver fibrosis. The study aimed to assess the relationship between NAFLD grades and lipid profiles in T2DM.Method. The design of the study was cross-sectional with the dependent variable being the grade of NAFLD and the independent variable being profile lipid. The sample of this study was NAFLD sufferers who met the inclusion criteria and were taken on a consecutive sampling basis. Diagnosis of NAFLD from anamnesis and physical, examination. Laboratory and abdominal ultrasound (Sonata SG 30 Ultrasound). Stages of NAFLD are divided into Degree I, Degree II, and Degree III. Lipid profile examination is carried out using a spectrophotometer tool colorimetric enzymatic method.Result. All patients are T2DM, consisting of Grade 1: 32 (40%), Grade II: 29 (36%), and Grade III: 19 (23%) patients. There was a significant difference between TC, TG, and LDL-C (p < 0.01) in the three grades of NAFLD. There is a significant correlation between NAFLD grade with TC and LDL-C (p < 0.05).Conclusion. In T2DM, there is a significant correlation between NAFLD grades and TC and LDL-C, and there was a significant difference between TC, TG, and LDL-C in the three grades of NAFLD.
Correlation Between the Ratio TG/HDL-C and Lipid Profile in Nonalcoholic Fatty Liver Disease Patients Siregar, Hafiz Syaifullah; M.Aron Pase
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 4 No. 1 (2022): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v4i1.8595

Abstract

Background: Insulin resistance is identified as an impaired biological response to insulin stimulation of target tissues primarily in the liver, muscle, and adipose tissue. The ratio TG/HDL-C has been proposed as a simple marker of insulin resistance. The study aimed to determine the correlation between the ratio TG/HDL-C and lipid profile in nonalcoholic fatty liver disease (NAFLD) patients Method: The design of the study was a cross-sectional study with the dependent variable Fibrosis Score of NAFLD sufferers who came to H. Adam Malik Medan General Hospital network hospital from July-September 2021. Diagnosis of NAFLD from anamnesis, physical examination, laboratory, and abdominal ultrasound. Lipid profile examination is carried out using a spectrophotometer tool colorimetric enzymatic method, observed include TC, HDL-C, LDL-C, and TG. Results: There are 80 NAFLD patients, aged 54.8±8.7 years, with uncontrol T2DM, and normal weight. There was a correlation significantly between the ratio TG/HDL-C with TC-C, TG, HDL-C, LDL-C (p<0.001), and no correlation between ratio TG/HDL-C with age, BMI, FPG, PPG, and HbA1c (p>0.05) Conclusion: There is a correlation between ratio TG/HDL-C (as a marker of insulin resistance) and lipid profile in NAFLD patients
Co-Authors Brama Ihsan Sazli Muhammad Aron Pase