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All Journal Indonesian Journal of Global Health research International Islamic Medical Journal
Tamarah, Elok
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Religion Humanities Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Drug Interactions in Coronary Heart Disease Patients : a Literature Review Tamarah, Elok; Handayani, Handayani; Ferdiantoro, Andik
Jurnal Medis Islam Internasional Vol 4 No 1 (2022): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v4i1.3856

Abstract

Background: Patients with coronary heart disease generally receive many drugs, such as hypercholesterolemia, antianginal, antiplatelet, anticoagulants, and medications for comorbid illnesses such as antihypertension and diabetes mellitus. Concomitant administration of several types of drugs may result in drug interactions. Objective : This study aims to figure out drug interactions that might occur in using combination drugs in patients with coronary heart disease. Methods: This article review uses the Google Scholar database, published 2017-2022. The keywords used were "coronary heart disease and drug interactions." The PRISMA flowchart is used to summarize the article selection process. Results: Administration of aspirin  with  clopidogrel  causes  a  moderate  synergistic  interaction,  whereas  administration  of antiplatelet agents with anticoagulants causes a significant synergistic interaction on bleeding. And the administration of  nifedipine  with  atorvastatin causes  a  synergistic  pharmacodynamic interaction. Conclusions: Drug interactions occur in patients with coronary heart disease, either synergistic or antagonistic pharmacodynamic interactions with minor, moderate, and significant classifications
The Effect of Deep Breathing Exercise Therapy Combination of Aromatherapy Based on Orem's Self Care Theory on Fatigue and Sleep Quality in Chronic Kidney Disease Patients Hemodialysis Tamarah, Elok; Soleha, Umdatus; Santy, Wesiana Heris; Hasina, Siti Nur
Indonesian Journal of Global Health Research Vol 7 No 1 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i1.4198

Abstract

Patients hemodialysis with experience complaints of anemia, fatigue, sleep disturbances, and increased urea levels. Fatigue and sleep disorders are still a high problem in Indonesia. Increased urea levels can cause decreased appetite, poor nutritional intake and complaints of fatigue. The aim of the research was to analyze the effect of deep breathing exercise therapy combined with Orem self-care based aromatherapy on fatigue levels and sleep quality. The design in this research is quasi-experimental. Population of all hemodialysis patients at RSI Jemursari Surabaya. The sample size was 40 people, divided into 2 groups, namely the intervention group and the control group. The sampling technique was taken using a total sampling technique. Data were analyzed using the independent t-test a < 0.05 and looking at the difference in values using the delta test. The results of research conducted at RSI Jemursari Surabaya, showed that the average fatigue score in the intervention group before giving deep breathing exercise therapy, a combination of aromatherapy based on self-care Orem, was 36.90 and after being given the intervention, it was found to decrease by 15.90, while the control group did not. given any therapy, according to hospital standards of 34.65 and experienced a decrease of 19.65. Based on the independent t - test, it shows p = 0.003 and sleep quality shows p = 0.001, which means that deep breathing exercise therapy combined with aromatherapy based on Orem self-care has an effect on fatigue and sleep quality. Deep breathing exercise therapy a combination of aromatherapy based on Self-Care Orem according to standards, can reduce fatigue levels and improve sleep quality.
Co-Authors Ferdiantoro, Andik Heris Santy, Wesiana Soleha, Umdatus Tamaulina Br Sembiring