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All Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Hosea, Fransiscus Nikodemus
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Medicine & Pharmacology

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Drug-induced Myelotoxicity in Patients with Crohn’s Disease Renaldi, Kaka; Hosea, Fransiscus Nikodemus
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 2 (2024): VOLUME 25, NUMBER 2, August, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2522024%p

Abstract

As a chronic granulomatous disease, Crohn’s disease (CD) poses a significant insinuation on morbidity and low quality of life. Long-term treatment is needed to control the disease activity. Observation and evaluation of disease activity are principal practices in treating CD, and sometimes clinicians tend to overlook the adverse effects of therapy that may occur and resemble disease progression.Hereby, we presented a 76-year-old female with a 10-year history of Crohn’s disease who came to our emergency room with general weakness one week before admission. She complained of hematochezia and abdominal pain in the last month. She had been taking mesalazine 2x500 mg PO and azathioprine 2x50 mg PO in the previous three years. She was diagnosed with lung cancer six months before admission and had been prescribed erlotinib 1x150 mg PO in the last six weeks. Upon admission, pancytopenia was found in the blood study. Hematochezia, along with anemia and abdominal pain, might occur due to either disease activity or the adverse effects of the medication.Thorough observation and clinical evaluation regarding disease activity and side effects are required to manage Crohn’s disease comprehensively. 
Diagnostic Approach and Management of Clostridium difficile Infection Hosea, Fransiscus Nikodemus; Fauzi, Achmad
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 3 (2023): VOLUME 24, NUMBER 3, December, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2432023250

Abstract

Clostridium difficile infection (CDI) was first viewed as a nosocomial infection as it is associated with antibiotics administration. But since antibiotics are more frequently to be prescribed in the community setting, clinicians should investigate the probability of all antibiotics-associated diarrhea as CDI.Diagnostic of CDI should be conducted cautiously as the manifestation of CDI varies from asymptomatic to fatal consequences and is associated with morbidity, mortality, recurrence risk, outbreak possibility, and low quality of life. Management of this infection should include infection prevention and control, stopping the offending antibiotics, and administration of specific antimicrobials.Clinicians should also recognize the risk of recurrence and the higher probability of less efficacious specific antimicrobials in each episode of recurrence.
Co-Authors Achmad Fauzi Kaka Renaldi