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Hapsari, Ariadne
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Medicine & Pharmacology

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PEMBERIAN ANTIBIOTIK PADA SEPSIS NEONATORUM Hapsari, Ariadne; Wijayana, Kamal Agung
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11437

Abstract

Neonatal sepsis is still an unsolved problem in newborn baby services and care. In developing countries, almost the majority of newborn baby treated are related to sepsis. The same thing was found in developed countries in babies treated in newborn baby intensive care units. In addition to morbidity. High mortality was also found in BBL sepsis sufferers. Neonatal sepsis is a clinical syndrome of systemic disease accompanied by bacteremia that occurs in the first 28 days of life. Bacterial, viral or fungal invasion into the blood before or after birth can spread to other organs/systems causing meningitis, pneumonia, osteomyelitis and pyelonephritis. Patient treatment usually involves giving a combination of antibiotics which aims to expand the range of pathogenic microorganisms that the patient may be suffering from. It is hoped that the combination of antibiotics will have good sensitivity to both Gram-positive and Gram-negative germs. Depending on the pattern and resistance of germs in each hospital, usually the antibiotics chosen are the ampicillin/ cloxacillin/ vancomycin group and the aminoglycoside/cephalosporin group. The length of treatment depends on the type of germ causing it. In patients with gram-positive bacteria, antibiotics are recommended for 10-14 days, while for patients with gram-negative bacteria, treatment can be continued for 2-3 weeks.
RELATIONSHIP BETWEEN MMP14 +7096 GENETIC VARIATION WITH CHILD TURCOTTE PUGH (CTP) SCORE IN HEPATIC CIRRHOSIS Wijayana, Kamal Agung; Siswandari, Wahyu; Hapsari, Ariadne; Yudha, Paskalis Bhaskara Unggul
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11438

Abstract

Background: Hepatic cirrhosis is chronic hepatic damage followed by structural change and decreased function of hepar. Child Turcotte Pugh (CTP) score is used to assess the severity of hepatic cirrhosis. Genetic variation of MMP14 has a role in the progressivity of liver diseases. Relationship between MMP14 +7096 genetic variation and Child Turcotte Pugh score in hepatic cirrhosis was not well known.Aim: To determine the relationship between MMP14 +7096 genetic variation with Child Turcotte Pugh score in hepatic cirrhosis patients in Prof. Dr. Margono Soekarjo General Hospital Purwokerto.Methods: Analytical observational study with cross-sectional design was conducted among 30 patients who were diagnosed hepatic cirrhosis in Prof. Dr. Margono Soekarjo General Hospital Purwokerto. Data collection was performed by total samping of blood laboratory test and PCR-RFLP. Data was analysed using Kruskal-Wallis test and Mann-Whitney post hoc test.Results: Kruskal-Wallis test shows relationship between genetic variation of MMP14 +7096 with Child Turcotte Pugh (CTP) score (p=0,024). Mann-Whitney post hoc test shows significant relationship between CC and TT genotype (p=0,02).Conclusions: There is a significant relationship between CC and TT genotype MMP14 +7096 genetic variation with Child Turcotte Pugh score in hepatic cirrhosis patients in Prof. Dr. Margono Soekarjo General Hospital Purwokerto.
COMPREHENSIVE REVIEW OF MECONIUM ASPIRATION SYNDROME: RISK FACTORS, COMPLICATIONS, AND TREATMENT APPROACHES Hapsari, Ariadne; Pratidina, Wening Gelar
Medical and Health Journal Vol 4 No 2 (2025): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.4.2.14996

Abstract

Background: Meconium Aspiration Syndrome (MAS) is a major cause of neonatal respiratory distress, occurring due to the aspiration of meconium-stained amniotic fluid. MAS can lead to airway obstruction, chemical pneumonitis, surfactant dysfunction, and persistent pulmonary hypertension. Objective: This article aims to review the risk factors, pathophysiology, diagnosis, complications, as well as prevention and management strategies of MAS based on recent literature. Methods: A literature review was conducted by analyzing relevant studies from scientific journals, medical textbooks, and other reliable sources. Results: MAS is associated with risk factors such as placental insufficiency, maternal hypertension, preeclampsia, and fetal hypoxia. Diagnosis is established through clinical assessment, radiological findings, and blood gas analysis. Management includes neonatal resuscitation, oxygen therapy, mechanical ventilation, and ECMO in severe cases. Conclusion: Early detection and appropriate management are crucial in reducing morbidity and mortality caused by MAS. Preventive strategies in the delivery room play a key role in reducing the risk of meconium aspiration and improving neonatal outcomes.
Co-Authors Kamal Agung Wijayana, Kamal Agung Pratidina, Wening Gelar Wahyu Siswandari Yudha, Paskalis Bhaskara Unggul