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All Journal IJOEP : International Journal of Ecophysiology
Said Aldi Palevi
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Agriculture, Biological Sciences & Forestry

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Antioxidative and Apoptotic Activities of Vernonia amygdalina Ethanolic Extract in the AOM/DSS Mice Model of Colon Cancer Said Aldi Palevi; Hasibuan, Poppy Anjelisa Zaitun; satria, denny
International Journal of Ecophysiology Vol. 6 No. 2 (2024): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v6i2.17290

Abstract

This study examined the efficacy and safety of Vernonia amygdalina ethanol extract (VAEE) therapy in treating azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colon cancer in mice, aiming to uncover the underlying mechanisms. A colon cancer mice model was used to evaluate the effects of VAEE on antioxidant enzyme levels and apoptosis. VAEE treatment increased SOD and caspase-3 levels while reducing MDA and Bcl-2 levels. These results indicate the potential of VAEE as an anticancer agent, with several doses showing significant increases in SOD and caspase-3 levels while significantly reducing MDA and Bcl-2 levels compared to the negative control (p<0.05). A dose of 500 mg/kg BW appears to be a potential candidate anticancer agent. Further studies on the molecular mechanisms and long-term effects are needed to support clinical applications. Keywords: Antioxidants, AOM/DSS, Apoptosis, VAEE, Colon Cancer
Co-Authors Denny Satria, Denny Hasibuan, Poppy Anjelisa Zaitun