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All Journal Jurnal Plastik Rekonstruksi
Handini, Nurliati Sari
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The Efficacy of Topical Tranexamic Acid in Breast Surgery Evaluating the Drain Output and Complications Reduction: A Systematic Review and Meta-Analysis Sudarman, Jesica Putri; Sayudo, Iqbal Farhan; Putri, Marcelvina Mutiara; Ali, Gary; Handini, Nurliati Sari
Jurnal Plastik Rekonstruksi Vol. 11 No. 1 (2024): Jurnal Plastik Rekonstruksi
Publisher : Lingkar Studi Bedah Plastik Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14228/

Abstract

Introduction : The topical administration of Tranexamic Acid (TXA) has gained significant attention for its potential advantages in various plastic surgery procedures. This study aims to conduct a systematic review and meta-analysis focusing on the use of topical TXA in breast surgery, analysing its impact on postoperative drain output and complications. Method : PubMed, Embase and the Cochrane Library databases were systematically searched to identify relevant studies. The data synthesis utilized random-effects models and the findings were presented as a mean difference and weighted odds ratio along with the corresponding 95% confidence interval. Results : Seven studies including four RCTs and three observational studies, comprising 1,553 breasts undergoing surgery were included. The average age of participants was 46 years; mean body mass index (BMI) was 26.1 kg/mm2. Of the breasts studied, 764 (49%) received topical TXA and 789 (51%) received normal saline as placebo. Overall, topical TXA was associated with a lower drain output in the first 24 hours postoperative (MD -25.87; p=0.00001) and a lower cumulative drain output (MD -59.72; p<0.00001). The rate of hematoma is significantly lower in the topical TXA group compared to the control group (OR 0.19; p=0.0009). There were no significant differences in rates of seroma, infection, thromboembolic events and time to drain removal between groups.   Conclusion: Evidence of this study suggests that administration of topical TXA significantly reduces the drain output production and hematoma in breast surgery. The use of topical TXA not significantly affecting rates of seroma, infection and postoperative duration with drain.
Large Abdominal Defect Closure: Case Series Handini, Nurliati Sari; Tiza, Melina; Sudjatmiko, Gentur
Jurnal Plastik Rekonstruksi Vol. 3 No. 1 (2016): Jurnal Plastik Rekonstruksi
Publisher : Lingkar Studi Bedah Plastik Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1227.145 KB) | DOI: 10.14228/jpr.v3i1.190

Abstract

Background: We will report some experiences in managing challenging malignant cases on the abdominal wall, including a case of large, irradiated defect. All of those cases were consulted intraoperative immediately following tumor removal. The keystone random perforator flap was chosen among the option of solutions in large abdominal defect closure. This region has natural elasticity, which combines well with the multi-axial tissue recruitment of the flap Methods: Three cases of complicated abdominal defect were reconstructed using the keystone flaps supplied by non-identified (random) perforators. Results: All flaps survived without problem of vascularization, despite of its large defect, sequence of radiotherapy following reconstruction, infection, and with its margin unable to be freed from tumor. One out of three cases suffered from contaminated wound from stomal leakage, leading to dehiscence. Conclusion: The keystone flap is a useful and reliable random perforator-based flap, even in complex and challenging malignant cases of abdominal wall.
Co-Authors Ali, Gary Putri, Marcelvina Mutiara Sayudo, Iqbal Farhan Sudarman, Jesica Putri Sudjatmiko, Gentur Tiza, Melina