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All Journal Chemistry Indonesian Journal of Chemical Research Jurnal Keperawatan
Indriani, Melly
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Biochemistry, Genetics & Molecular Biology Chemistry Engineering Environmental Science Nursing

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Efektivitas Pemberian Kombinasi Tablet Fe dan Vitamin C terhadap Peningkatan Kadar Haemoglobin pada Ibu Hamil Yulianti, Ika; Jumain, Susianti; Indriani, Melly; Sefti, Sefti
Jurnal Keperawatan Vol 16 No 2 (2024): Jurnal Keperawatan: Juni 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/keperawatan.v16i2.1753

Abstract

Anemia defisiensi besi paling sering dialami ibu hamil yang dapat mengganggu pertumbuhaln sel-sel otak, sehingga dapat mengakibatkan perdarahan sebelum dan selama persalinan, kelahiran premature, berat badan lahir rendah, keguguran pada ibu hamil, yang paling buruk adalah kematian pada ibu dan janinnya.  Terapi yang tepat sangat diperlukan untuk mengatasi anemia. Tujuan penelitian ini adalah untuk menganalisis perbandingan terapi menggunakan tablet Fe dengan kombinasi vitamin C dengan peningkatan kadar haemoglobin. Desain penelitian adalah eksperimen semu di Puskesmas Gunung Lingkas, Kota Tarakan, Provinsi Kalimantan Utara. pada bulan Mei-juni 2023. Sampel penelitian sebanyak 90 orang. Pemberian tablet Fe 200 mg dilakukan selama 14 hari dengan jumlah 28 butir dikonsumsi 2 x 1 sehari selama 2 minggu, pada kelompok intervensi diberikan tablet Fe 200 mg ditambah pemberian vitamin C 100 mg selama 14 hari. Analisis uji beda data yang digunakan adalah independent t test. Hasil analisis uji beda dapat dilihat perbedaan rerata antara kelompok intervensi (Pemberian Fe dan Vitamin C) adalah 11,5 mmHg, hasil ini lebih tinggi dibandingkan kelompok kontrol (pemberialn talblet Fe) yaitu hanya 10,6 mmHg. Setelah dianallisis menggunakan uji beda di dapatkan hasil p vallue 0.003 < 0.005.
Formulation and Characterization of Uncaria gambir (U. gambir) Extract Cream as an Anti-Psoriasis Candidate: In Silico and In Vitro Studies Abidin, Khoirul Rista; Nurhidayattulloh, Ariffialdi; Siregar, Febrina; Dermawan, Abdurrafi Maududi; Dwisari, Fath; Oktaviria, Oktaviria; Suchi, Suchi; Indriani, Melly; Putri, Firda Aulia; Prasetyaningsi, Hernyati; Shofia, Shofia
Indonesian Journal of Chemical Research Vol 13 No 3 (2026): Edition for January 2026
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2026.13-kho

Abstract

Background: Psoriasis is a chronic inflammatory skin disorder in which oxidative stress and COX-2–mediated pathways contribute to disease progression. Conventional topical therapies, particularly corticosteroids, are effective but associated with adverse effects and limited mechanistic targeting. Objective: This study investigated Uncaria gambir (U. gambir) extract as a natural anti-psoriasis candidate in a topical cream formulation through phytochemical, antioxidant, in silico, and physicochemical evaluations. Methods: The extract was screened for phenolic and flavonoid content and evaluated for DPPH radical scavenging activity (IC₅₀). Molecular docking of catechin against the COX-2 receptor was performed using quercetin as a reference. Cream formulations containing varying extract concentrations were assessed for pH, spreadability, and adhesiveness. Results: U. gambir extract exhibited very strong antioxidant activity (IC₅₀ = 6.84 ppm), falling within the range of highly active antioxidants, although less potent than vitamin C. Catechin showed stable COX-2 binding (−4.76 kcal/mol). The 4.5% cream formulation (F2) demonstrated optimal properties, with a skin-compatible pH (~7.5) and good spreadability (~5.5 cm). Conclusion: U. gambir extract shows promising potential as a natural topical agent targeting oxidative stress and inflammation in psoriasis, supporting further in vivo and clinical validation.
Co-Authors Abidin, Khoirul Rista Dermawan, Abdurrafi Maududi Jumain, Susianti Mochammad Imron Awalludin Nurhidayattulloh, Ariffialdi Oktaviria, Oktaviria Prasetyaningsi, Hernyati Putri, Firda Aulia Sefti, Sefti Shofia, Shofia Siregar, Febrina Suchi, Suchi