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All Journal Diponegoro International Medical Journal (DIMJ)
Rayhan, Amar
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Medicine & Pharmacology Neuroscience

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Liquid Smoke and Hydrogel Membrane as Burn Wound Healing Properties Rayhan, Amar
Diponegoro International Medical Journal Vol 4, No 1 (2023): July 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i1.16382

Abstract

Background : Anyone has the potential to get injured, especially burns. Hydrogel membrane and liquid smoke are a combination of antibacterial, anti-inflammatory and antioxidant properties. These properties play an important role in wound healing. In wound healing, the re-epithelialization process is a critical parameter for the success of wound closure.Aim : Analyzed the effect of re-epithelialization length on burns of rats given a liquid smoke combination hydrogel membrane.Methods : Experimental research used post test only with control group design. The number of samples was 15 white wistar rats with burns which were divided into two treatment groups, namely P1 (liquid smoke combination hydrogel membrane), P2 (liquid smoke) and one control group K (hydrogel membrane). Assessment of reepithelialization length has been calculated using a microscope. Statistical test using One Way ANOVA – Post Hoc Bonferroni test.Results : The average length of re-epithelialization (µm) for each group was (P1) 2004.91, (P2) 1534.15 and (K) 1248.16. Based on the results of the One Way ANOVA analysis, we found p value  = 0.028 (p <0.05). This shows that there were significant differences in the data between groups.Conclusions : There was a significant difference on the length of re-epithelialization in rats burn wound between hydrogel membrane group with liquid smoke, liquid smoke group and control group.
Comparison of Intravenous Ephedrine Administration of 5 mg and 10 mg Doses on Post Spinal Anesthesia Hypotension in Caesarean Section at Dr. Kariadi General Hospital Semarang Alaydrus, Husein; Rayhan, Amar; Arifin, Johan; Satoto, Hari Hendriarto
Diponegoro International Medical Journal Vol 6, No 1 (2025): July 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i1.26813

Abstract

Background: Hypotension after spinal anesthesia or combined epidural anesthesia in caesarean section (CS) causes adverse effects on the mother and fetus/neonatal. Hypotension often occurs therefore vasopressors could be used routinely and should be used as prophylaxisMethods: Simple randomized controlled trial study of 52 patients undergoing CS at RSUP dr. Kariadi Semarang. Subjects revealed two groups, namely intravenous ephedrine at a dose of 5 mg and a dose of 10 mg. Hemodynamic variables were measured every 3 minutes until the operation was completed.Results: In the comparison of mean arterial pressure (MAP) between the ephedrine 5 mg and ephedrine 10 mg groups, a statistically significant difference was obtained at 30 minutes (P < 0.05) while in the measurement of heart rate (HR) between the ephedrine 5 group mg and ephedrine 10 mg, a statistically significant difference was obtained from 3 to 15 minutes. Hypotension was obtained in 1 patient in the ephedrine 10 mg group and 3 patients in the ephedrine 5 mg group.Conclusion: 10 mg intravenous ephedrine as a prophylactic agent after spinal anesthesia for patients undergoing CS has better hemodynamic outcomes and complications than 5 mg intravenous ephedrine. Keywords: spinal anesthesia, ephedrine, SC, hypotension
Co-Authors Hari Hendriarto Satoto Husein Alaydrus, Husein Johan Arifin