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All Journal Nusantara Science and Technology Proceedings Sriwijaya Journal of Internal Medicine
Santoso, Hidayat
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing

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A Systematic Review and Meta-Analysis: The Long-Term Effects of Oral N-Acetylcysteine in Chronic Obstructive Pulmonary Disease Nasikhatussoraya, Nova; Umam, Hamid Faqih; Rizkani, Ainingtyas Marda; Santoso, Hidayat
Nusantara Science and Technology Proceedings The 4th International Conference on Community Medicine and Medical Sciences
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2024.4404

Abstract

Chronic obstructive pulmonary disease (COPD) is one of the world's most prevalent causes of morbidity and mortality. About 5.6% of Indonesians have COPD. Most COPD patients have mucus hypersecretion and inadequate mucus clearance, leading to airway obstruction. N-acetylcysteine (NAC) is a mucolytic drug with antioxidant and anti-inflammatory effects. Long-term oral NAC use in COPD remains controversial. We searched four databases to analyze the effects of oral NAC in COPD over a minimum six-month treatment. The data was analyzed through Review Manager 5.4. Eight randomized controlled trials, comprising 3.187 patients, were selected for inclusion in the study. NAC had a lower risk of exacerbations (RR 0.78, 95% CI 0.66-0.93; p=0.005), whether at high dose (1200mg/day) or low dose (600mg/day). The risk is higher at the high dose (RR 0.90, p=0.04) than at the low dose (RR 0.70, p=0.0002). NAC did not affect FEV1 (mean difference 4.71, 95% CI -3.20-12.61; p=0.24), and adverse events were the same as with placebo (RR 1.14, 95% CI 0.78-1.67; p=0.51). Long-term oral NAC reduces the risk of COPD exacerbations at any dose and was well tolerated.
Overview of Microorganisms Causing Urinary T ract Infections at Cut Meutia General Hospital, North Aceh, Indonesia Santoso, Hidayat; Ali, Zulfikar
Sriwijaya Journal of Internal Medicine Vol. 1 No. 1 (2023): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v1i1.205

Abstract

Introduction: Urinary tract infection (UTI) is a general term that refers to the presence of microorganisms in the urine. Bacteria and fungi are the causative agents of urinary tract infections, which can be found in the urine of someone who is indicated to be suffering from a urinary tract infection. This study aimed to provide an overvie w of microorganisms that cause urinary tract infections in Cut Meutia General Hospital, North Aceh, Indonesia. Methods: This study is a descriptive observati onal study. A total of 100 research subjects participated in this study. Data analysis on the distribution of microorganisms that cause UTIs was carried out in a univariate. Results: The majority of microorganisms that cause urinary tract infections are Escherichia coli. In addition, other microorganisms as the cause of urinary tract infections are Klebsiella pneumoniae, Acinetobacter baumannii, Proteus mirabilis, Klebsiella oxytoca, and Pseudomonas aeruginosa. Conclusion: Escherichia coli is the most common microorganism that causes urinary tract infections at Cut Meutia General Hospital, North Aceh, Indonesia.
Co-Authors Nova Nasikhatussoraya, Nova Rizkani, Ainingtyas Marda Umam, Hamid Faqih Zulfikar Ali, Zulfikar