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All Journal Scientific Journal of Dermatology and Venereology
Zhou, Suyong
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Health Professions

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A Randomized Controlled Trial Evaluating the Impact of Dietary Supplementation with Polyphenols on Disease Severity and Quality of Life in Adults with Moderate to Severe Atopic Dermatitis in Beijing, China Zhou, Suyong; Jinfang Zhang
Scientific Journal of Dermatology and Venereology Vol. 1 No. 2 (2023): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v1i1.41

Abstract

Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin condition that significantly affects quality of life. Polyphenols, with their anti-inflammatory and antioxidant properties, offer a potential therapeutic avenue for AD management. Methods: This randomized, double-blind, placebo-controlled trial enrolled adults with moderate to severe AD in Beijing. Participants were randomized to receive either a polyphenol-rich dietary supplement or a placebo for 12 weeks. The primary outcome was the change in Scoring Atopic Dermatitis (SCORAD) index. Secondary outcomes included quality of life assessment using the Dermatology Life Quality Index (DLQI), and serum inflammatory markers. Results: A total of 120 participants completed the trial. The polyphenol group showed a significantly greater reduction in SCORAD index compared to the placebo group (p < 0.001). DLQI scores also improved significantly in the polyphenol group (p < 0.01). Furthermore, serum levels of inflammatory markers, including C-reactive protein and interleukin-6, decreased significantly in the polyphenol group. Conclusion: Dietary supplementation with polyphenols may offer a safe and effective adjunctive therapy for improving disease severity and quality of life in adults with moderate to severe AD.
Antioxidant Potential in Atopic Dermatitis: A Systematic Review Zhou, Suyong; Jinfang Zhang
Scientific Journal of Dermatology and Venereology Vol. 1 No. 1 (2023): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v1i1.195

Abstract

Introduction: Various antioxidants have been investigated for their potential role in managing atopic dermatitis. These include vitamins such as vitamins E and C, minerals like selenium, plant-derived polyphenols like green tea and resveratrol, and natural compounds like curcumin. These antioxidants possess diverse mechanisms of action, ranging from scavenging free radicals to modulating inflammatory pathways, and have shown promising results in preclinical and clinical studies. This study aimed to conduct a systematic study of the antioxidant potential in atopic dermatitis. Methods: The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the potential of antioxidants in atopic dermatitis. This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. Results: Antioxidant compounds such as vitamin E, vitamin C and flavonoids in each of the studies showed potential clinical improvement in atopic dermatitis patients. Conclusion: Antioxidant compounds have potential as supplementation for the management of atopic dermatitis.
Co-Authors Jinfang Zhang