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All Journal Indonesian Journal of Obstetrics & Gynecology Science Medical and Health Journal
Sumawan, Herman
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Health Professions Medicine & Pharmacology Public Health

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Maternal Characteristics of Very Low Birth Weight and Extremely Low Birth Weight Incidence Pajajaran, Badar Muhammad; Sumawan, Herman; Judistiani, Raden Tina Dewi; Handono, Budi
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.654

Abstract

Introduction: Low birth weight (LBW) infants have the potential for cognitive deficits, motor delays, cerebral palsy, and other behavioral and psychological problems. Household expenses and health care system costs can be reduced by alleviating the burden of LBW. Currently, there are no available data on the maternal characteristics of very low birth weight (VLBW) and extremely low birth weight (ELBW) incidence in Indonesia.Method: This was a retrospective analytical observational study with a cross-sectional design. The sample in this study included all infants born with a birth weight of <1500 grams at Margono Purwokerto Hospital during 2018-2022. Univariate and bivariate analyses were performed using a significance level of p≤0.05.Results: A total of 65 patients in the ELBW group and 59 patients in the VLBW group were included in this study. Statistical test results showed no significant differences in the characteristics of age, parity, birth weight of the infant, criteria for hypertension during pregnancy, criteria for anemia, comorbidities, hospital treatment, postpartum care, and type of delivery. The variables that differed significantly were anemia (Hb VLBW vs Hb ELBW; 9.06 vs 8.21) and neonatal outcomes.Conclusion: There was no difference between the maternal characteristics of the incidence of very low birth weight and extremely low birth weight, except for anemia. Checking hemoglobin levels in patients with ELBW is essential for providing appropriate treatment.Karakteristik Ibu dengan Bayi Berat Badan Lahir Sangat Rendah dan Kejadian Berat Badan Lahir Sangat RendahAbstrakPendahuluan: Bayi dengan berat badan lahir rendah (BBLR) berpotensi mengalami defisit kognitif, keterlambatan motorik, Cerebral Palsy, serta permasalahan perilaku dan psikologis lainnya. Pengeluaran rumah tangga dan biaya sistem pelayanan kesehatan dapat dikurangi dengan meringankan beban BBLR. Saat ini belum tersedia data mengenai karakteristik ibu dengan kejadian berat badan lahir sangat rendah (BBLR) dan berat badan lahir sangat rendah (BBLSR) di Indonesia.Metode:Penelitian ini merupakan penelitian observasional analitik retrospektif dengan desain cross-sectional. Sampel dalam penelitian ini meliputi seluruh bayi yang lahir dengan berat badan lahir <1500 gram di RS Margono Purwokerto selama tahun 2018-2022. Analisis univariat dan bivariat dilakukan dengan tingkat signifikansi p≤0,05.Hasil:Sebanyak 65 pasien pada kelompok BBLR dan 59 pasien pada kelompok BBLSR dilibatkan dalam penelitian ini. Hasil uji statistik menunjukkan tidak terdapat perbedaan bermakna pada karakteristik umur, paritas, berat badan lahir bayi, kriteria hipertensi saat hamil, kriteria anemia, penyakit penyerta, perawatan di rumah sakit, perawatan nifas, dan jenis persalinan. Variabel yang berbeda secara signifikan adalah anemia (Hb BBLSR vs Hb BBLR; 9,06 vs 8,21) dan luaran neonatal.Kesimpulan:Tidak terdapat perbedaan karakteristik ibu terhadap kejadian berat badan lahir sangat rendah dan berat badan lahir sangat rendah, kecuali anemia. Pemeriksaan kadar hemoglobin pada pasien BBLR sangat penting untuk memberikan pengobatan yang tepat.Kata kunci: bayi berat lahir sangat rendah, BBLSR, bayi berat lahir sangat rendah, BBLR
Neutrophil- Lymphocyte Ratio (NLR) and Platelet- Lymphocyte Ratio (PLR) as Inflammatory Markers in Preterm Birth Izzah, Muthiah Nurul; Sumawan, Herman; Achmad, Eppy Darmadi
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 2 Juli 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i2.671

Abstract

Introduction: Preterm births make up roughly 16–18% of all live births in Indonesia. One of the factors that contribute to preterm birth is inflammation. The study aimed to assess the role of platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR) as inflammatory markers in preterm birth. Method: This is a cross-sectional retrospective Study. Data were collected from medical records at Margono Soekarjo Hospital, January 2022-February 2023. The cohort comprised 150 participants with singleton pregnancies, ranging from 28 to less than 37 weeks of gestation, divided into three groups: preterm birth without preterm premature rupture of membranes (PPROM), preterm birth with PPROM, and threatened preterm labor (TPL). Multivariate ANOVA tests were employed for data analysis. Result: There was a statistically significant difference NLR values , notably in preterm births without PPROM compared to other groups (p value < 0.005), whereas the only difference noted in PLR values was noted between preterm births with and without PPROM. Our finding differs from that of previous studies, which indicated higher NLR values in preterm births with PPROM.Conclusion: NLR and PLR have the potential to be used as inflammatory markers indicative of heightened risk of preterm birth.Rasio Neutrofil-Limfosit (RNL) dan Rasio Platelet-Limfosit (RPL) sebagai Penanda Inflamasi pada Persalinan PrematurAbstrakPendahuluan: Angka kejadian persalinan prematur di Indonesia mencakup 16-18% dari semua kelahiran hidup. Inflamasi atau infeksi dianggap sebagai salah satu penyebab persalinan prematur. Penelitian ini bertujuan untuk menilai peran rasio trombosit/limfosit (PLR) dan rasio neutrofil/limfosit (NLR) sebagai penanda inflamasi pada kelahiran premature.Metode: Penelitian merupakan studi retrospektif cross-sectional. Data dikumpulkan dari rekam medis RSUD Margono Soekarjo periode Januari 2022 - Februari 2023. Didapatkan 150 pasien hamil tunggal dengan rentang usia kehamilan 28 hingga kurang dari 37 minggu yang terbagi dalam tiga kelompok: kelahiran prematur tanpa ketuban pecah dini (KPD), kelahiran prematur dengan KPD, dan ancaman persalinan prematur. Tes ANOVA multivariat digunakan untuk analisis data.Hasil: Terdapat perbedaan nilai NLR yang signifikan secara statistik, terutama pada kelahiran prematur tanpa KPD dibandingkan dengan kelompok lain (nilai p <0,005), sedangkan perbedaan nilai PLR hanya terdapat pada kelahiran prematur dengan dan tanpa KPD. Temuan kami berbeda dengan penelitian sebelumnya yang menunjukkan nilai NLR lebih tinggi pada kelahiran prematur dengan KPD.Kesimpulan: NLR dan PLR berpotensi digunakan sebagai penanda inflamasi yang mengindikasikan peningkatan risiko kelahiran prematur.Kata kunci: NLR, PLR, persalinan prematur
Microrna Profile of Plasma Exosomes by Nanostrings in Early Onset Compared Late Onset Preeclampsia: Preliminary Study Sumawan, Herman; Pradjatmo, Heru; Hadiati, Diah Rumekti; Mubarika, Sofia; Giantari, Ifrinda
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17598

Abstract

Research on miRNA biomarkers in preeclampsia as part of screening, diagnosis, and prognosis has been widely conducted, but the results show contradictory results and vary based on the type of preeclampsia. This study aims to compare the profile of plasma exosome miRNA in early onset compared late onset as a preliminary study to identify the miRNA profile of preeclampsia patients in Indonesia. The study was conducted at Margono Hospital,Indonesia using plasma exosomes samples of three patients with early-onset preeclampsia and three patients with late-onset preeclampsia and processed with NanoStrings. KEGG was used to identify preeclampsia pathophysiological pathways by bioinformatic analysis of DIANA-miRPath v3.0 and microT-CDS v5.0. The results showed that the characteristics of parity, hemoglobin, systolic and diastolic blood pressure, proteinuria and BMI did not differ between EOPE and LOPE. Significantly different variables were the age of the EOPE (28 ± 5.29) vs LOPE (38.67 ± 2.06 mmHg), pregnancy weight gain (10.0 vs 15.33), and fetal weight in EOPE (1550 ± 132 g) vs LOPE (2693 ± 716 g). The results showed that the 24 miRNAs differed significantly. The three highest expression miRNAs in the EOPE group were miR-196b-5p, miR-190a-5p, and miR-515-3p. In contrast, the three lowest expression miRNAs are miR-3179, miR-181a-5p, and miR-15b-5p. Pathway analysis of the upregulated miRNA involved the ErbB signalling pathway, Proteoglycan in cancer, and Lysin degradation. Downregulated miRNA targets involved in the HIPPO signalling pathway, fatty acid biosynthesis, and TGF-β signalling pathway. Conclusions: The preliminary study results indicated significant differences in miRNA expression, suggesting that EOPE is influenced by aggressive cellular signaling and metabolic dysregulation, while LOPE is more linked to the disruption of growth-inhibiting pathways and fatty acid metabolism. These unique miRNAs establish a robust foundation for subsequent validation studies utilizing bigger samples as a prospective biomarker panel.
Co-Authors Budi Handono Diah Rumekti Hadiati Eppy Darmadi Achmad Heru Pradjatmo Ifrinda Giantari Izzah, Muthiah Nurul Pajajaran, Badar Muhammad Raden Tina Dewi Judistiani Sofia Mubarika Haryana