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All Journal HAYATI Journal of Biosciences Indonesian Journal of Dental Medicine YARSI Medical and Dental Science (YASMINE)
Alwan, Maryam Hameed
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Agriculture, Biological Sciences & Forestry Dentistry Earth & Planetary Sciences

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Histological and Molecular Evaluation of the Antiproliferative Activity of Allium ampeloprasum Water Extract Against Oral Mucosa Cell Line (Gingival Cancer) Alwan, Maryam Hameed; Hameed, Zainab; Mandala, Satria
HAYATI Journal of Biosciences Vol. 31 No. 5 (2024): September 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.5.829-835

Abstract

Gingival carcinoma is a malignant neoplasm affecting the oral mucosa and is associated with significant morbidity and mortality. Allium ampeloprasum var. porrum water extracts have gotten a lot of attention because of their bioactive components, such as polyphenols, flavonoids, and alkaloids, which have a variety of pharmacological activities, including antiproliferative actions. This study aimed to evaluate the histological and molecular effects of Allium ampeloprasum (leek) water extract on the proliferation of the murine gingival cancer cell line. Histological evaluation was conducted to examine morphological changes induced by extract treatment. Molecular mechanisms underlying the observed histological changes were investigated using real-time polymerase chain reaction (PCR). Expression levels of key genes associated with cell proliferation and apoptosis were assessed. Histological findings revealed a dose-dependent decrease (100, 50, 25, 12.5, and 6.25 µg/ml) in cell density and altered cell shape in the treated cell line. Also, the percentage of inhibition for the oral mucosa cell line was high, with a significant P of 0.006, in the treated group compared to the control group. Additionally, water extract has an IC50 value of 61 g/ml. The P53 fold increment of gene expression is 0.6, which means the expression level in the experimental condition is 60% higher than the control. This study provides evidence for the potential antiproliferative activity of Allium ampeloprasum water extract on the oral mucosa cell line. The observed histological changes, coupled with the modulation of key genes involved in proliferation and apoptosis, suggest that leek water extract may have therapeutic implications in managing oral cancer.
Impact of VAPE use on dental and oral health among male dental students Khalaf, Mohammed Hassan; Alwan, Maryam Hameed
Indonesian Journal of Dental Medicine Vol. 8 No. 1 (2025): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v8i1.2025.1-5

Abstract

Background: The emergence of vaping as a popular alternative to traditional smoking has raised concerns regarding its potential impact on oral health. specifically affects the oral health of dental students, who are not only consumers of these products but also future practitioners tasked with educating patients on oral hygiene and health risks. purpose: This study investigated the dental and oral health impact of VAPE among male dental students. Methods: A self-administered questionnaire comprising 20 questions was meticulously designed to gather relevant data about their VAPE use and its implications on dental and oral health. Results: 43% of participants reported using VAPE, predominantly employing salt nicotine (48.8%) over free base nicotine (27.9%). The dental health statuses, assessed using the Decayed, Missing, and Filled Teeth (DMFT) index, showed that 35.6% had a DMFT score of 3 or higher, while 37.6% had scores below 3, and 26.7% reported a DMFT of 0. Most participants (57.4%) visited the dentist rarely, with no distinction between VAPE users and non-users. However, significant differences in aspects such as breathing, sleep quality, and fitness were noted between VAPE users and non-users (p:0.002, p:0.05, and p:0.00; p<0.05), respectively. Conclusion: As E-cigarettes smoking is becoming more widely growing habit within the young age group, more oral and physiological consequences begin to rise, such as a significantly higher prevalence of mouth dryness, cough and ultimately, worsened bodily functions including a lower breathing quality and reduced level of fitness.
Oral Biopsy: Evaluating Awareness and Knowledge Among Dental Students at University of Baghdad: Oral Biopsy: Evaluating Awareness and Knowledge Among Dental Students alwan, maryam hameed; Dania Mahdi A. Alhussain; Tiba Haider Muneer
YARSI Dental Scientific Meeting - e Journal Vol 2 No 1 (2025): YARSI Medical and Dental Science (YASMINE) Journal
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/yasmine.v2i1.5789

Abstract

Introduction Oral biopsy is a fundamental diagnostic procedure in dentistry, essential for the early detection of oral cancer and other pathologies. While theoretical knowledge is a core component of dental education, the translation of this knowledge into clinical confidence and practical ability is critical for patient care. Objective: : evaluate the awareness, knowledge, and self-perceived ability to perform oral biopsies Material and Methods: A cross-sectional study was conducted among dental students. Participants (n=110) comprising 14 multiple-choice questions assessing key variables: knowledge of biopsy principles, techniques, lesion identification, specimen preservation, and ability to perform the procedure Results: While theoretical awareness was high (98% knew what a biopsy is), a significant gap existed with practical application. Only 16% of students felt confident performing a biopsy independently. The primary barriers were reliance on theoretical knowledge only (47%) and a lack of clinical training (37%). A statistically significant association was found between gender and the perceived ability to perform a biopsy (p=0.002). However, no significant correlation was found between academic stage (4th vs. 5th year) and practical ability (p=0.2). Conclusion: Dental students have a strong theoretical foundation in oral biopsy but report a significant deficit in practical, hands-on training and self-confidence. The findings highlight a critical need to reform the curriculum to include more clinical and simulation-based training to bridge this theory-practice gap and better prepare future dentists for this essential diagnostic responsibility
Co-Authors Dania Mahdi A. Alhussain Hameed, Zainab Khalaf, Mohammed Hassan Satria Mandala Tiba Haider Muneer