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All Journal PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Indonesian Journal of Science and Pharmacy Indonesian Journal of Medical and Pharmaceutical Science
Rahayu, Nila Rusdi
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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COMPARED EFFECTIVENESS, SAFETY AND COST OF DEXMEDETOMIDINE WITH MIDAZOLAM: A REVIEW Rahayu, Nila Rusdi; Mutripah, Siti
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 2 No. 2 (2023): APRIL
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v2i2.881

Abstract

Dexmedetomidine, an alpha 2 receptor agonist sedative drug, has recently garnered attention as a viable alternative to midazolam, a widely used benzodiazepine for sedation in adult patients. The aim of this study was to conduct a comprehensive comparison of the clinical sedative efficacy, cost-effectiveness, and safety profiles of dexmedetomidine versus midazolam, utilizing a randomized controlled trial design. The search encompassed several databases, including PubMed, Scopus, Web of Knowledge, CINAHL, the United States National Library of Medicine, and Google Scholar for Systematic Reviews, using the keywords 'dexmedetomidine,' 'midazolam,' and 'effectiveness.' The findings revealed that dexmedetomidine demonstrated a more favorable safety profile, with a lower incidence of delirium compared to midazolam. In terms of effectiveness, no significant differences were observed between the two drugs for local sedation. Notably, adult patients treated with dexmedetomidine had a shorter Intensive Care Unit (ICU) stay (7 days) compared to those receiving midazolam (10 days). Similarly, pediatric ICU treatment indicated a shorter duration with dexmedetomidine (20 hours) as opposed to midazolam (38 hours). Regarding cost-effectiveness, dexmedetomidine emerged as a cost-saving option, being approximately 10% cheaper than midazolam for adult ICU patients. These findings collectively highlight the advantages of dexmedetomidine over midazolam, encompassing superior safety, effectiveness, and cost-efficiency, thus providing valuable insights for healthcare practitioners and decision-makers.
Aktivitas Antidiabetes Ekstrak Etanol Daun Jambu Biji (Psidium guajava L.) terhadap Analisis Berat Badan Tikus yang Diinjeksi Streptozotocin Rahayu, Nila Rusdi; Badriyah, Lailatul; Mutripah, Siti
Indonesian Journal of Medical and Pharmaceutical Science Vol. 4 No. 2 (2025)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v4i2.448

Abstract

Background: Diabetes mellitus (DM) refers to a medical condition impacting the body's metabolism of lipids, carbohydrates, and proteins, stemming from issues with pancreatic endocrine hormones like insulin and glucagon. This study aimed to test the ability of ethanol extract from guava leaves to reduce blood glucose levels in rats injected with streptozotocin (STZ), and to evaluate the effect of the ethanol extract on food consumption. Methods: This antidiabetic test was conducted on rats injected with streptozotocin (STZ) by measuring the increase in blood glucose levels and body weight in rats experiencing hyperglycemia. The experimental animals were split into four categories, and each category had six rats. The rats in Group I received regular sustenance, the rats in Group II were given CMC Na solution, the rats in Group III received 5mg/kg BW of gliclazide, and the rats in Group IV were administered 300mg of guava leaf extract. A 40mg/kg BW streptozotocin injection was given intraperitoneally on day 0. Blood glucose levels were assessed on days 7, 14, and 21. Data analysis used oneway Anova and followed by The Kolmogorov-Smirnov test was used to assess the normality of the blood glucose and body weight data. Results: The results of study showed On day 21, a significant difference was seen between the STZ-injected group with EEDJ extract treatment 300mg/kg bb and the STZ-injected group intraperitoneally and given Gliclazide 5 mg/kg BW (p<0.05), but there was no significant difference. Conclusion: Administration of EEDJ extract and gliclazide has shown a significant decrease in blood glucose levels and greatly prevent weight loss.
Formulation and Evaluation of Hydrocarbon Ointment from 96% Ethanol Extract of Red Tender Leaves (Syzygium myrtifolium Walp.) Stiyani, Rintika Isa; Mutripah, Siti; Rahayu, Nila Rusdi; Badriyah, Lailatul; Alfiza, Ibnu Syinna
Indonesian Journal of Science and Pharmacy Vol. 3 No. 1 (2025): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v3i1.105

Abstract

Red Shoot Leaf (Syzigium myrtifolium Walp) has chemical compounds of alkaloids, steroids, triterpenoids, flavonoids, phenolics, and saponins, and has the antibacterial effect of Staphylococcus aureus. This study aims to find out whether Red Shoot leaf extract can be formulated in ointment preparations with hydrocarbon bases and determine the opimal formulation based on physical evaluation. The research was conducted using an experimental method.  Red Shoot leaf extract (Syzigium myrtifolium Walp) was obtained by maceration using 96% ethanol solvent. The extract is formulated into an ointment preparation with three different formulas, namely formula 1 with a variation in the concentration of cera alba 4%, formula 2 with a concentration of cera alba 8% and formula 3 with a concentration of cera alba 12%. The results of the ointment preparations were then evaluated organoleptically, homogeneity, pH, and dispersibility. Based on the results obtained in the spreadability test, it has decreased. The preparation that has the greatest dispersion is found in formula I where the concentration of cera alba used is 4%, while the lowest dispersion is found in formula III with a concentration of cera alba of 12%. Meanwhile, judging from the evaluation of organoleptic, homogeneity, and pH, the three formulas have met the requirements. It can be concluded that 96% ethanol extract of Red Shoot leaves (Syzigium myrtifolium Walp) can be formulated into hydrocarbon ointment preparations and meet the optimal formula requirements, namely 4% and 8% alba cera concentrations.
Co-Authors Alfiza, Ibnu Syinna Lailatul Badriyah Mutripah, Siti Stiyani, Rintika Isa