Hospital management requires fast and accurate data management to create quality services. This study aims to evaluate the Hospital Management Information System (SIMRS) at Efarina Etaham Berastagi Hospital. The design of this research is quantitative research with a cross sectional approach. This research was conducted at the Efarina Etaham Berastagi Hospital, Karo Regency, North Sumatra Province. The time of the research was carried out from July 2022 to February 2023. The population in this study were all employees who used the Hospital Management Information System (SIMRS) in their work at the Efarina Etaham Berastagi Hospital in 2022 totaling 110 people consisting of department employees medical department. The number of samples taken in this research was 110 people. The variable measurements used are system use, user satisfaction, structure, environment, system quality, information quality, service quality, net benefits. Research data collection instruments are primary, secondary and tertiary. The data analysis used is univariate, bivariate and multivariate analysis. From the research results, it is known that there is a relationship between system use and SIMRS performance, there is a relationship between user satisfaction and SIMRS performance, there is a relationship between structure and SIMRS performance, there is a relationship between the environment and SIMRS performance, there is a relationship between system quality and SIMRS performance, there is a relationship between information and SIMRS performance, there is relationship between service quality and SIMRS performance. The suggestion in the research is that it is necessary to carry out preventive maintenance/maintenance regularly and periodically as well as monitoring maintenance on SIMRS regarding hardware and software in related units. Hospital management needs to pay attention to factors that encourage or hinder the adoption of SIMRS as a reference in SIMRS development, such as network improvements and also improving computer facilities for users.Keyword : Hospital, Hospital Management Information System, Quality