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All Journal Journal of Bioresources and Environmental Sciences
Ben-Attia, Mossadok
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Earth & Planetary Sciences Environmental Science

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Efficacy of Tribulus terrestris on diabetes and sexual disorders: A narrative review Bouabdallah, Salwa; Ben-Attia, Mossadok; Eldahshan, Omayma A
Journal of Bioresources and Environmental Sciences Vol 3, No 3 (2024): December 2024
Publisher : BIORE Scientia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61435/jbes.2024.19935

Abstract

Tribulus terrestris L. (T. terrestris) is widely distributed worldwide (Australia, Europe, India, North Africa). It typically contains a substantial amount of active ingredients, especially saponins, alkaloids, flavonoids, tannins, terpenoids, and phenol carboxylic acids. Additionally, T. terrestris has been frequently used in folk medicine and as a food supplement, highlighting the importance of evaluating its phytopharmacological properties. Various hypotheses suggest that this species may have significant potential in preventing and improving various human conditions, including diabetes, inflammatory diseases, low sexual desire, and infertility. Phytochemical studies reveal a significant disparity in the content of active substances, with a notable gap in the concentrations of spirostanol saponins and furostanol, which are the predominant active ingredients associated with therapeutic effects. The objective of this present review is to evaluate T. terrestris -based formulations by exploring various potential mechanisms of action, aiming to determine whether the use of T. terrestris supplements is justified in the context of diabetes and its complications. 
Investigating flavonoids derived from Tribulus terrestris L. as prospective candidates for Alzheimer's disease treatment: Molecular docking modeling of their interactions with physiological system receptors Bouabdallah, Salwa; Azzouz, Rahma; Al-Khafaji, Khattab; Ben-Attia, Mossadok
Journal of Bioresources and Environmental Sciences Vol 3, No 2 (2024): August 2024
Publisher : BIORE Scientia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61435/jbes.2024.19931

Abstract

Alzheimer's disease (AD) stands as the primary cause of dementia, marked by its neurodegenerative essence, which results in cognitive impairment associated with memory and a decline in functionality. Currently there is no drug which can permanently cure the nervous lesions as well as completely eradicate this pathogenesis. The aim of this research is to examine the acetylcholinesterase activity of flavonoids identified in Tribulus terrestris L. (Tt) by predicting ligand-receptor binding. The research process begins with the preparation of protein and ligand structures. Subsequently, docking is performed, interaction between protein-ligands is then analyzed and visualized. Four phytoconstituents of Tt were chosen, and molecular docking simulations revealed that all four compounds exhibited good binding affinities. Based on the predicted ADMET values using the Lipinski rule, compounds with potentially good activity were identified. The results suggest that these compounds may exhibit anti-acetylcholinesterase activity.
Co-Authors Al-Khafaji, Khattab Azzouz, Rahma Bouabdallah, Salwa Eldahshan, Omayma A