Chandra, Cindy Christella
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Partial Least Squares Regression Analysis Between Body Mass Index, Abdominal Circumference, Hip Circumference, Hemoglobin, Body Composition, Uric Acid, Blood Sugar, Hemoglobin and Hematocrit with Face Analyzer in Adults Tan, Sukmawati Tansil; Christian, Farell; Chandra, Cindy Christella; Firmansyah, Yohanes
Malahayati Nursing Journal Vol 6, No 12 (2024): Volume 6 Nomor 12 (2024)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v6i12.15873

Abstract

ABSTRACT Skin is an important aspect of the human body. Many factors may influence skin health and its characteristics, including physiological and metabolic conditions such as obesity, blood sugar, hemoglobin and hematocrit, and uric acid. To establish a correlation between physiological and metabolic health parameters with skin-face analysis (roughness and wrinkles). This research was conducted in Kalam Kudus Foundation, West Jakarta, targeting individuals ≥17 years old, both men and women, following the inclusion and exclusion criteria. Skin health parameters used were roughness and wrinkles. The metabolic parameters studied were body mass index (BMI), waist circumference (WC), hip circumference (HC), body composition, blood sugar, hemoglobin (Hb), hematocrit (Ht), and uric acid. Our research shows negative coefficient results of BMI (-0,076 and –0,059), WC (-0,844 and -0,795), Hb (-0,069 and -0,074), Ht (-0,112 and -0,161), and uric acid (-0,155 and -0,170) with skin roughness and wrinkle. Other parameters such as HC (0,294 and 0,323), blood glucose (0,141 and 0,058), total body fat mass (0,321 and 0,345), visceral fat (0,234 and 0,203), total subcutaneous fat (0,319 and 0,391), and total muscle mass (0,725 and 0,890) result in a positive coefficient with skin roughness and wrinkle. An increase in BMI, WC, Hb, Ht, and uric acid is associated with better skin roughness and wrinkles while higher hip circumference, total body fat mass, visceral fat, total subcutaneous fat, total muscle mass, and blood sugar may worsen the skin condition. Keywords: Obesity, Blood Sugar, Hemoglobin, Hematocrit, Uric Acid, Skin Roughness, Wrinkles
Efficacy, Effectiveness, and Safety of Combination Cream (Clindamycin 3%, Tretinoin 0.05%, and Dexamethasone 0.05%) Over Their Monotherapy (Tretinoin 0.05%) in Acne Vulgaris Patients: Scaled-Up Retrospective Cohort Study Tan, Sukmawati Tansil; Firmansyah, Yohanes; Hendsun, Hendsun; Chandra, Cindy Christella
MAHESA : Malahayati Health Student Journal Vol 4, No 9 (2024): Volume 4 Nomor 9 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i9.15463

Abstract

ABSTRACT Acne vulgaris is an inflammatory disorder that impacts pilosebaceous glands, affecting many adolescents physically and psychologically. The finest acne cream comprises retinoids, antibiotics, and corticosteroids. Accuracy of acne vulgaris therapy affects the healing and prognosis. To compare the efficacy of a single topical cream containing 0.05% Tretinoin to a combination cream containing Clindamycin 3%, Tretinoin 0.05%, and Dexamethasone 0.05%. This was a retrospective cohort study that included 1027 respondents, observing the result of using 2 types of creams for treating acne: 1) a single tretinoin 0.05% cream and 2) a combination cream therapy (Clindamycin 3%, Tretinoin 0.05%, and Dexamethasone 0.05%). The evaluated parameters were mean reduction in acne lesions quantity as the main objective and other side parameters (Spot, Pore, Wrinkle, UV moisture, UV damage, Roughness, Porphyrin, Pigmentation, and Hydration) as the secondary goals. This study shows that there was a significant difference both in primary and secondary endpoints between single tretinoin 0.05% cream and combination cream therapy (Clindamycin 3%, Tretinoin 0.05%, and Dexamethasone 0.05%) with p-value <0.05 in all parameters. As for adverse events, there was no statistically significant difference locally, and no incidence was found systemically. Combination cream (Clindamycin 3%, Dexamethasone 0.05%, and Tretinoin 0.05%) might provide superior primary and secondary efficacy parameters in acne treatment than single tretinoin cream. Keywords: Acne vulgaris, Safety, Effectiveness, Tretinoin, Clindamycin, Dexamethasone