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All Journal Indonesian Journal of Chemistry
Hussein, Kawther Adeeb
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Chemical Engineering, Chemistry & Bioengineering Chemistry

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Microwave-Assisted, Preparation, Characterization, and Biological Activities of Schiff Bases Derived from 4-Aminoantipyrine with Acetonyl Acetone for Some New Rare-Earth Metals Hussein, Kawther Adeeb; Shaalan, Naser; Faeq, Marwa
Indonesian Journal of Chemistry Vol 24, No 5 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.95419

Abstract

Five new lanthanide complexes based on azomethine (Schiff bases) ligands have been synthesized, including La, Nd, Er, Gd, and Dy. Complexes were synthesized using the azomethine Schiff bases resulting from condensation reactions between 4-aminoantipyrine and acetonylacetone. The structural characteristics of azomethine obtained are characterized quantitatively and qualitatively through various techniques, including elemental analyses, magnetic susceptibility measurement, molar conductivity, infrared, ultraviolet absorption, GC-mass, and 1H- and 13C-NMR spectroscopy studies. The structural characteristics of Ln+3 complexes indicate that the complexes possess a composition of a specific type. Based on the elemental analyses, magnetic susceptibility measurement, molar conductivity, and ultraviolet absorption spectroscopy data, it can be inferred that the central metal ion is surrounded by a coordination number of 10, the general formula of [Ln(L)2(NO3)]·nNO3nH2O. The physical measurements confirmed that the synthesized complexes exhibit non-electrolyte behavior and paramagnetic properties. The antibacterial activity of the compounds was assessed in vitro against 4 pathogenic strains: E. coli, S. aureus, K. pneumoniae, and S. mutans. The evaluation was conducted using the agar disc spreading method. The results demonstrated that certain complexes exhibited significant antibacterial efficacy in comparison to the biological activity of the ligand.
Study of Bioactivity and Physicochemical Properties of New Metal Chelates of Schiff Base Derived from 4-Aminoantipyrine with Cysteine Hussein, Kawther Adeeb; Ali, Dina Naseer; Faeq, Marwa
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.111223

Abstract

Transition metallic complexes Cr, Co, Ni, Mn, and Cu were designed and prepared using a new bidentate chelator ligand from 4-aminoantipyrine with cysteine. The products were characterized using various analytical, spectroscopic, and theoretical methods. According to the various analysis data, the azomethine-Schiff base chelator linked with metallic cations as a neutral bidentate chelator exhibited distorted octahedral and tetrahedral structures, with protonated and deprotonated carboxyl oxygen and azomethine nitrogen atoms in a molar ratio of 1:2 metal: ligand in a structure of [M(L)2Cl2]·nH2O and [M(L)2]·Cl2nH2O. According to mass spectroscopy, the molecular weights of the azomethine-Schiff base closely match those estimated by m/z. Additionally, Fourier-transform infrared (FTIR), ultraviolet-visible (UV-vis), 1H-NMR, and 13C-NMR spectra, LC-MS, magnetic moment, and molar conductance were used to study the structure of the azomethine-Schiff base ligand and metallic complexes. The antibacterial activity was tested against Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, and Acinetobacter baumannii, while the antifungal activity was evaluated against Candida albicans, Candida parapsilosis, Candida lusitaniae, and Candida tropicalis. The free ligand showed negligible activity, whereas its metal complexes exhibited moderate to strong antimicrobial effects, confirming that metal coordination significantly enhances biological potency.
Co-Authors Ali, Dina Naseer Faeq, Marwa Shaalan, Naser