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All Journal Neurona Indonesian Journal of Biomedicine and Clinical Sciences
Setyawan, Tommy Rachmat
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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C-reactive protein (CRP) and lactate dehydrogenase (LDH) as functional outcome predictors in stroke patients Nadhilla, Nyimas Farisa; Gofir, Abdul; Setyawan, Tommy Rachmat; Farida, Siti; Ar Rochmah, Mawaddah
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 3 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i3.15893

Abstract

Stroke is a neurologic disorder with high mortality and disability. Its pathophysiology is associated with vascular inflammation. However, studies between vascular inflammatory markers and stroke outcomes are still limited. This study aimed to investigate the association between inflammatory markers and functional outcomes of stroke. This was a retrospective cohort study involving all stroke patients at the Dr. Sardjito General Hospital, Yogyakarta from October 2020 to August 2021 who meet the inclusion and exclusion criteria. Mann-Whitney was used for bivariate analysis, followed by multivariate analysis. A total of 269 subjects, with 213 infarcts (79.2%) and 56 hemorrhagic (20.8%) strokes. There were 83 subjects deceased (30.9%), with 66 infarct (31%) and 17 hemorrhagic (30.4%) strokes. High CRP levels had significant and independent associations with worse GCS, ADL, IADL, NIHSS, BI, SSGM, MRS, and higher mortality rates (p < 0.05). High LDH levels had a significant and independent association with worse GCS scores and higher mortality rates (p < 0.05). Sub-analysis showed high CRP and LDH had associations with high mortality rates in infarct (p < 0.001), but only CRP (p = 0.029) had associations with high mortality rates in hemorrhagic. There was no significant association between fibrinogen and procalcitonin with stroke outcomes (p > 0.05). Cox-regression analysis showed CRP>24.5 mg/dL and LDH >300U/L associated with hazard ratios of 3.2 (p < 0.001) and 1.65 (p = 0.026). In conclusion. high CRP and LDH levels are associated with mortality rates in stroke patients.
TROMBEKTOMI MEKANIS DAN TROMBOLISIS INTRAARTERI PADA STROKE ISKEMIK: FOKUS PADA LUARAN KLINIS Listyawan, Rakhian; Setyawan, Tommy Rachmat
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 5: Edisi Suplemen Neurona Bekerjasama dengan JogjaCLAN 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i5.864

Abstract

Mechanical thrombectomy has become the standard recommended therapy for acute ischemic stroke due to large vessel occlusion. A series of fundamental clinical trials have demonstrated the superiority of mechanical thrombectomy in achieving functional independence (modified Rankin Scale [mRS] score 0-2) at 90 days compared to medical therapy alone. The therapeutic window for mechanical thrombectomy has even been extended to 24 hours for selected patients based on perfusion imaging. Meanwhile, the role of intraarterial thrombolysis has evolved from primary therapy to an adjunctive or rescue strategy, used in cases of incomplete recanalization or distal embolism after mechanical thrombectomy. Both treatment modalities continue to evolve to improve clinical outcomes in patients. Keywords: Ischemic stroke, mechanical thrombectomy, intraarterial thrombolysis, large vessel occlusion, clinical outcome.
Co-Authors Abdul Gofir Listyawan, Rakhian Mawaddah Ar-Rochmah Nadhilla, Nyimas Farisa Siti Farida