In an era of rapid technological advancements and increasing global competition, organizations must adopt integrated strategies to enhance performance, foster innovation, and ensure long-term sustainability. This study explores the interplay between leadership, technology, Total Quality Management (TQM), and sustainability in driving organizational excellence across multiple sectors. Through a systematic literature review, this research synthesizes insights from recent studies to examine how these four dimensions collectively shape organizational performance. The findings highlight that transformational leadership plays a crucial role in fostering employee engagement, knowledge sharing, and strategic decision-making, particularly when aligned with sustainability initiatives. The integration of artificial intelligence (AI), business intelligence (BI), and digital transformation has been identified as a key enabler of operational efficiency and data-driven decision-making, although challenges such as technostress and resistance to change persist. Moreover, TQM practices contribute significantly to service quality, customer satisfaction, and continuous organizational learning, especially when combined with digital tools and leadership-driven quality improvement strategies. Lastly, sustainability-driven business practices, including green supply chain management (SCM) and corporate social responsibility (CSR), have emerged as fundamental drivers of competitive advantage and long-term organizational resilience. This study provides both theoretical and practical implications, offering a comprehensive framework that integrates leadership, technology, quality management, and sustainability for enhanced organizational performance. The research underscores the need for cross-sectoral best practices, strategic leadership, and investment in digital transformation and sustainability initiatives. Future research should focus on empirical validations, sector-specific variations, and innovative frameworks that optimize these interdependencies. This study contributes to academic discourse and managerial practice by offering valuable insights for policymakers, business leaders, and researchers navigating the complexities of modern organizational environments.