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Belatriks Kalangit, Ruth
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Metode uji sitotoksisitas biomaterial dengan  bentuk scaffold padatan dan berpori spons Belatriks Kalangit, Ruth; Octarina
Jurnal Kedokteran Gigi Terpadu Vol. 6 No. 1 (2024): Jurnal Kedokteran Gigi Terpadu
Publisher : Fakultas Kedokteran Gigi Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/jkgt.v6i1.20886

Abstract

Three-dimensional scaffolds play a crucial role in supporting cell growth and tissue regeneration, especially in bone regenerative applications. Their utilization in dentistry demands effective cytotoxicity assessment, particularly for sponge-shaped scaffolds with a unique porous structure fostering a complex environment for cell growth. Therefore, the imperative lies in selecting cytotoxicity testing methods suitable for these characteristics. Relevant methods for such scaffolds include MTS, Alamar Blue, ATP, CCK-8, and MTT assays. MTS assay efficiently measures cell viability in a three-dimensional setting, while Alamar Blue and CCK-8 assays, with their water-soluble nature and high reproducibility, prove advantageous. ATP assay provides direct insights into cellular metabolic activity, and MTT assay assesses cell viability based on enzymatic capabilities. Due to their water-soluble characteristics, minimizing additional extraction steps, and ensuring high reproducibility, Alamar Blue and CCK-8 emerge as the most fitting options for cytotoxicity assessment in dentistry's sponge-shaped scaffolds.
Co-Authors Octarina