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Carissa Nurhasinah Wiriawan, Deandra
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Hubungan penyakit periodontal dengan covid-19 Suwandi, Trijani; Carissa Nurhasinah Wiriawan, Deandra
Jurnal Kedokteran Gigi Terpadu Vol. 6 No. 1 (2024): Jurnal Kedokteran Gigi Terpadu
Publisher : Fakultas Kedokteran Gigi Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/jkgt.v6i1.20908

Abstract

Periodontitis is a chronic, multifactorial, inflammatory disease, associated with plaque biofilms and characterized by the progressive destruction of the tooth-supporting structures. Periodontal diseases can increase the inflammatory response in patients, which might exacerbate the systemic symptoms and clinical course of coronavirus (COVID-19). The potential association of periodontitis and COVID-19 severity can be explained by the alteration in the expression of cellular receptors enhancing the virulence of SARS-CoV-2 and by periodontal pockets acting as viral reservoirs. These associations between periodontitis and COVID could be due to the fact that both diseases share common immune pathways such as the NF-κB pathway, NLRP3/IL-1β pathway, and IL-6 signaling pathway as well as common risk factors such as gender, lifestyle, and comorbidities. This suggests that the two diseases may be linked through the same genetic pathway.  
Co-Authors Trijani Suwandi