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All Journal The International Journal of Medical Science and Health Research The Indonesian Journal of General Medicine
Nugraha, Dhimas Mohammad Fajar
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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The Analysis Study of Efficacy and Safety of Topical Anesthetic Agent for Treatment of Premature Ejaculation: A Comprehensive Systematic Review Nugraha, Dhimas Mohammad Fajar; Akmalia, Tsalitsa Laili
The International Journal of Medical Science and Health Research Vol. 2 No. 2 (2024): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/zzyzqk73

Abstract

Background: Premature ejaculation (PE) affects 20-30% of men globally, with lifelong and acquired types requiring diverse behavioral and pharmacological treatments. This systematic review aims to analyze current evidence on the efficacy and safety of topical anesthetic agent for treatment of premature ejaculation based on literatures of the last 10 years. Methods: The study adhered to PRISMA 2020 standards, examining English literature from 2014 to 2024. PubMed, SagePub, SpringerLink, and Google Scholar were utilized as literature sources. Result: Initially retrieving 360 articles from online databases (PubMed, SagePub, SpringerLink and Google Scholar) six relevant papers were selected after three rounds of screening for full-text analysis. Conclusion: Overall, the evidence suggests that topical anesthetic agents are effective in treating PE. These agents consistently improve IELT and patient satisfaction, with a favorable safety profile. The findings also highlight the importance of individualized treatment approaches, considering patient preferences, sexual habits, and the specific characteristics of PE.
The Analysis Study of Efficacy, Effectiveness, and Clinical Risk of Tramadol as Treatment of Premature Ejaculation : A Comprehensive Systematic Review Nugraha, Dhimas Mohammad Fajar; Akmalia, Tsalitsa Laili
The Indonesian Journal of General Medicine Vol. 2 No. 1 (2024): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/eafb0p31

Abstract

Background: Premature ejaculation is a common sexual dysfunction affecting 20%-30% of men. Understanding the effectiveness and potential dangers of tramadol in treating premature ejaculation can help develop efficient treatment protocols. Methods: In accordance with the PRISMA 2020 principles, this systematic review focused specifically on comprehensive English literature published from 2013 to 2024. Result: The study examined over 2000 papers from respectable sources such as Science Direct, SagePub, and PubMed. Following the decision to subject eight publications to further scrutiny, a comprehensive examination of the complete body of literature was conducted. Conclusion: Tramadol, an analgesic derived from opioids, effectively suppresses premature ejaculation (PE) and enhances sexual satisfaction during sexual intercourse. Nevertheless, the efficacy and safety of its use in treating PE are still a subject of discussion due to a lack of solid empirical evidence. Additional investigation is required to ascertain the effectiveness of the medication and its possible adverse effects.
Co-Authors Akmalia, Tsalitsa Laili