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All Journal Indonesian Journal of Global Health research The International Journal of Medical Science and Health Research
Christian, Stedi Adnyana
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Dentistry Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Veterinary

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The Analysis Study of The Effect of Intraosseus Infiltration of Platelet Rich Plasma for Knee Osteoarthritis : A Comprehensive Systematic Review Gede, Odi Bayu Dharma Perkasa; Christian, Stedi Adnyana
The International Journal of Medical Science and Health Research Vol. 3 No. 1 (2024): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/9npnce52

Abstract

Background: Knee osteoarthritis (KOA) is an active, heterogeneous, and low-grade inflammatory condition leading to functional disability and pain. The aim: The aim of this study to show about the effect of intraosseus infiltration of platelet rich plasma for knee osteorthritis. Methods: By the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. Result: Eight publications were found to be directly related to our ongoing systematic examination after a rigorous three-level screening approach. Subsequently, a comprehensive analysis of the complete text was conducted, and additional scrutiny was given to these articles. Conclusion: Intraosseous (IO) PRP injections to target subchondral bone can provide a more comprehensive treatment by stimulating biological processes that lead to an environment primed for regeneration. Restoring joint homeostasis also influences the behaviour of MSCs that coordinate bone remodelling of the subchondral bone.
Comparison of Platelet-Rich Plasma with Corticosteroid Injections for Patients with Mild to Moderate Carpal Tunnel Syndrome: A Systematic Review and Meta-Analysis of Current Evidence in Randomized Controlled Trials Kusuma, I Made Wira; Karna, Made Bramantya; Asmara, Anak Agung Gde Yuda; Christian, Stedi Adnyana
Indonesian Journal of Global Health Research Vol 6 No S6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6iS6.4580

Abstract

Carpal tunnel syndrome (CTS) accounts for over 90% of peripheral entrapment neuropathy cases. Platelet-rich plasma (PRP), has shown promise due to its anti-inflammatory effects and potential to support axonal repair and neuronal regeneration. The aim of this study is to evaluate the comparative therapeutic efficacy of PRP and corticosteroid injections in treating mild to severe CTS, using a three-month follow-up period.Methods: This meta-analysis followed the PRISMA framework, reviewing studies from 2017 to 2022 in PubMed and the Cochrane Library that compare PRP and corticosteroid injections for CTS. Primary outcome including Visual Analog Scale (VAS), Sensory Peak Latency (SPL), Distal Motor Latency (DML), and the Boston Carpal Tunnel Questionnaire Symptom Severity Scale (BCTQ-SSS). Results: Four studies remained after matches the screening phase. This meta-analysis includes 245 patients, including 123 receiving PRP and 122 corticosteroid injections. When looking at the VAS 1 and 3 month periods, FSS 3 months, SSS 3 months, DML 1 and 3 months, and SPL 3 months, there were statistically significant changes better outcomes towards PRP injection group compared to the control group. Conclusion: PRP injections provided better short- to mid-term relief and improved electrophysiological outcomes compared to corticosteroid injections in mild to moderate CTS cases.
Co-Authors Asmara, Anak Agung Gde Yuda Gede, Odi Bayu Dharma Perkasa Karna, Made Bramantya Kusuma, I Made Wira