Article Per Year (5 Year)
p-Index From 2020 - 2025
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This Author published in this journals
All Journal The International Journal of Medical Science and Health Research The Indonesian Journal of General Medicine
Setiafadi, Rachmad Alsy
Unknown Affiliation
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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The Analysis Study of Association of Intestinal Microbiota and Kidney Disease: A Comprehensive Systematic Review Setiafadi, Rachmad Alsy; Nida, Nor Anisatun; Marom, Muhammad Naufal
The International Journal of Medical Science and Health Research Vol. 4 No. 1 (2024): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/yeqq9170

Abstract

Background: Disruptions in gut microbiota compositiosn (dysbiosis) in kidney diseases can lead to worsened kidney function. Dysbiosis may increase intestinal permeability and systemic inflammation, allowing bacterial toxins to enter the bloodstream and exacerbate CKD and its complications. This systematic review aims to evaluate the association of intestinal microbiota and kidney disease by analyzing available studies of the last 10 years. Methods: The study adhered to PRISMA 2020 standards, examining English literature from 2014 to 2024. It excluded editorials, reviews from the same journal, and submissions without a DOI. PubMed, SagePub, SpringerLink, and Google Scholar were utilized as literature sources. Result: Initially retrieving 360 articles from online databases (PubMed, SagePub, SpringerLink and Google Scholar) eight relevant papers were selected after three rounds of screening for full-text analysis. Conclusion: Gut microbiota alterations are closely linked to chronic kidney disease (CKD) and end-stage renal disease (ESRD), impacting inflammation and disease progression. Microbial shifts offer potential diagnostic and therapeutic insights, though further research is needed for clinical application.
The Analysis Study of Effects of Oral Antidiabetic Drugs on Tuberculosis Risk and Treatment Outcomes : A Comprehensive Systematic Review Setiafadi, Rachmad Alsy; Nida, Nor Anisatun; Marom, Muhammad Naufal
The Indonesian Journal of General Medicine Vol. 3 No. 1 (2024): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/adhbdc07

Abstract

Background: Diabetes mellitus triples the risk of infection, leading to poor clinical outcomes. Hyperglycemia suppresses immune responses, affecting TB and diabetes patients. Modulation of host cell responses and targeting pathogens could improve treatment outcomes and reduce drug resistance. Methods: Following PRISMA 2020 guidelines, this systematic review focused exclusively on full-text articles published in English between 2014 and 2024. Result: The study conducted a comprehensive review of over 600 publications sourced from reputable databases, including ScienceDirect, SagePub, and PubMed. Following an initial screening, eight publications were identified as warranting more in-depth analysis. Consequently, a thorough review of these selected studies was performed to ensure a detailed and rigorous evaluation. Conclusion: Metformin, an oral antidiabetic (OAD) agent, is associated with reduced incidence and mortality from active tuberculosis in patients with diabetes. In contrast, saxagliptin, another oral antidiabetic drug, is linked to an increased risk of active tuberculosis. The continuing examination of the association between metformin and tuberculosis risk highlights the need for further research to better elucidate and validate these associations.
Co-Authors Marom, Muhammad Naufal Nor Anisatun Nida, Nor Anisatun