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Kamilovich, Ochilov Alisher
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Achievements and Prospects of Treatment of Chronic Gastritis Kamilovich, Ochilov Alisher; Saidovna, Ochilova Gulrukh
Academia Open Vol 7 (2022): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.7.2022.5716

Abstract

This article presents a comprehensive examination of the influence of genetic factors on individual drug response in pharmacotherapy, emphasizing the potential for personalized medicine and minimizing the risk of adverse drug reactions. The study aims to explore the goals, methods, results, and implications of incorporating modern approaches to personalized pharmacotherapy. By understanding the role of genetics in drug response, physicians and researchers can envision improved methods of tailoring treatments to individual patients, ultimately reducing the likelihood of side effects and optimizing therapeutic outcomes. This article highlights the promising prospects of personification of pharmacotherapy, highlighting the potential for revolutionizing medical practice and enhancing patient care. Highlights: Influence of genetic factors: This article examines the significant impact of genetic factors on an individual's response to drugs in pharmacotherapy, highlighting the importance of understanding genetic variations for personalized treatment. Personalized medicine potential: The study explores the potential for personalized pharmacotherapy, aiming to tailor drug treatments based on an individual's genetic profile, with the goal of minimizing side effects and optimizing therapeutic outcomes. Enhancing patient care: By considering genetic factors, healthcare professionals can anticipate a reduction in adverse drug reactions and improve treatment effectiveness, leading to enhanced patient care and better treatment outcomes. Keywords: Genetic factors, personalized pharmacotherapy, individual drug response, side effects, treatment outcomes.
Efficacy and Safety of Pharmacotherapy of Chronic Gastritis Saidovna, Ochilova Gulrukh; Kamilovich, Ochilov Alisher
Academia Open Vol 7 (2022): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.7.2022.5717

Abstract

The MDR-1 gene encodes P-glycoprotein, a vital membrane protein found in various normal cells throughout the body. This protein plays a crucial role in actively facilitating the absorption of drugs across cell membranes. Understanding the expression of P-glycoprotein is essential for comprehending drug pharmacokinetics and optimizing pharmacotherapy outcomes. In this study, our goal was to investigate the influence of P-glycoprotein expression on drug permeability and its implications for therapeutic effectiveness. Through a comprehensive analysis of existing literature, we explored the methods employed to assess P-glycoprotein activity and its impact on drug absorption. The results unveiled the pivotal role of P-glycoprotein in modulating drug permeability and highlighted its significance in determining pharmacotherapy outcomes. This research emphasizes the necessity of considering P-glycoprotein expression when designing drug delivery strategies, enabling targeted therapies, and maximizing therapeutic efficacy. Highlights: P-glycoprotein: Key regulator of drug permeability and cellular absorption. Influence of P-glycoprotein expression on pharmacotherapy outcomes. Importance of considering P-glycoprotein in drug delivery and targeted therapies. Keywords: MDR-1 gene, P-glycoprotein, drug permeability, pharmacokinetics, pharmacotherapy effectiveness.
Co-Authors Saidovna, Ochilova Gulrukh