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Saadoon, Israa Hashim
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Serum Pentraxin-3 as a Potential Biomarker for Early Detection of Diabetic Nephropathy in Type 2 Diabetes Mellitus: A Cross-Sectional Study Khdher, Noor Naji; Ahmeid, Mutaz Sabah; Saadoon, Israa Hashim; Hassan, Alaa Abdullah
Academia Open Vol 8 No 2 (2023): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.8.2023.7971

Abstract

This cross-sectional study aimed to assess the utility of serum Pentraxin-3 (PTX-3) as a biomarker for the early identification of diabetic nephropathy (DN) in patients with Type 2 Diabetes Mellitus (T2DM). A total of 90 participants, including 30 with T2DM and nephropathy, 30 with T2DM but without nephropathy, and 30 controls, were enrolled. Serum PTX-3 levels were measured, and correlations with clinical parameters were analyzed. The results revealed a significant elevation in serum PTX-3 levels in DN patients with T2DM. PTX-3 exhibited positive correlations with age, disease duration, blood urea, and serum creatinine, indicating its potential relevance to DN development and renal function. Conversely, non-significant negative correlations were observed with BMI and estimated glomerular filtration rate (eGFR). These findings suggest that serum PTX-3 could serve as a valuable biomarker for the early detection of diabetic nephropathy in Type 2 Diabetes Mellitus, potentially aiding in timely intervention and improved patient care. Highlights : Serum PTX-3 levels significantly elevated in Type 2 Diabetes patients with nephropathy, highlighting its potential as an early diagnostic biomarker. Positive correlations observed between PTX-3, age, disease duration, blood urea, and serum creatinine, suggesting its relevance to DN development and renal function. Serum PTX-3 holds promise for timely identification of diabetic nephropathy, facilitating improved patient care. Keywords : Diabetic Nephropathy, Pentraxin-3, Type 2 Diabetes, Biomarker. Early Detection
Adenovirus Genotype 7 Detection in Adults with Respiratory Infection and Elevated IL-6: Deteksi Genotipe Adenovirus 7 pada Dewasa dengan Infeksi Pernafasan dan Kadar IL-6 yang Tinggi Ahmed Tofiq, Wirya; Saadoon, Israa Hashim
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.258

Abstract

Background (General): Human adenoviruses are widespread pathogens responsible for a significant proportion of respiratory tract infections, with genotype 7 (HAdV-7) associated with severe outcomes. Background (Specific): Despite its clinical importance, limited data exist regarding the prevalence and immunological impact of HAdV-7 among adult patients in Iraq. Knowledge Gap: The relationship between HAdV-7 infection and interleukin-6 (IL-6) levels in adults with respiratory illness has not been well characterized. Aim: This study aimed to detect HAdV-7 in adult patients with respiratory infections using RT-PCR and to evaluate its association with IL-6 levels. Results: Among 100 patients and 50 healthy controls, HAdV-7 was detected in 7% of cases, with no significant association with age, sex, or residence. Patients infected with HAdV-7 exhibited significantly elevated IL-6 levels (101.75 ± 25.17 pg/mL) compared with controls (39.26 ± 11.09 pg/mL, p ≤ 0.05). Novelty: This is one of the first molecular investigations in Iraq to link HAdV-7 infection with heightened IL-6 responses, highlighting the virus’s role in driving inflammatory pathways. Implications: Monitoring IL-6 levels may serve as a biomarker for disease severity in HAdV-7 infections and support timely therapeutic interventions to reduce complications.Highlight : HAdV-7 detection by RT-PCR shows its link with increased IL-6 levels. Molecular methods enhance sensitivity for early diagnosis. IL-6 monitoring can guide prognosis and therapy. Keywords : ELISA, RT-PCR, HAdV, Respiratory Infection, IL-6
Co-Authors Ahmed Tofiq, Wirya Ahmeid, Mutaz Sabah Hassan, Alaa Abdullah Khdher, Noor Naji