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All Journal Jurnal Elementaria Edukasia Indonesian Pharmacopeia Journal (IPJ)
khairun nisa, nadia
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Chemistry Education Health Professions Medicine & Pharmacology Other

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Peningkatan Hasil Belajar Siswa Pada Pembelajaran Tematik Terpadu Menggunakan Model Kooperatif Tipe Numbered Head Together Di Kelas III SD khairun nisa, nadia; Risda Amini
Jurnal Elementaria Edukasia Vol. 6 No. 2 (2023): Juni
Publisher : Elementary Teacher Education Program, Majalengka University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jee.v6i2.5499

Abstract

In Class III SDN 01 Sungai Geringging, the Numbered Head Together Type Cooperative Model to Improve Learning Outcomes in Integrated Thematic Learning is the focus of this study. 25 participant including teachers and class III students—were used as research subjects. By combining qualitative and quantitative methods, this study is a classroom action research (CAR). Research findings demonstrate: (1) RPP increased from cycle I's average percentage of 81.25% with a good predicate (B) to cycle II's very good (A) percentage of 97.5%. (2) Cycle I had an implementation rate of 82.81% with a good predicate (B), whereas cycle II had an implementation rate of 93.75% with an excellent predicate (A). The characteristics of the pupils increased from cycle I, where the average percentage was 82.81% with an excellent predicate (B), to cycle II, when the proportion was 93.75% very good (A). (3) Cycle I had an average percentage of 77.82% with an excellent predicate (B), and cycle II had an average percentage of 87.17% with a very good predicate (A) in student learning outcomes. Thus, in class III SDN 01 Sungai Geringging, Padang Pariaman Regency, the cooperative model of the Numbered Head Together type was able to enhance student learning results in integrated thematic learning.
IN SILICO STUDY OF SOYBEAN (Glycine max L.) ISOFLAVONES FOR ANTI-BREAST CANCER THROUGH HER2 TARGETING Tri Agustin, Ayu; Khairun Nisa, Nadia; Karnasih, IGA; Rofik Usman, Mohammad; Mayasari, Shinta
Indonesian Pharmacopeia Journal Vol. 2 No. 2 (2025): 31 July 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i2.45

Abstract

One of the cancers with the most excellent death rates worldwide, including in Indonesia, is breast cancer. Elevated HER2 expression significantly contributes to breast cancer progression by stimulating cell proliferation. Targeted therapies such as trastuzumab have limitations due to potential side effects. This study aims to identify the possible role of soybean (Glycine max L.) isoflavone compounds in inhibiting HER2 using an in silico approach prediction of physicochemical properties, pharmacokinetics, and bioactivity through SwissADME and PASS Online. The Hex 8.0.0 docking tool and Biovia Discovery Studio 2019 looked into how molecules interact with each other in complicated ways. Our study revealed that physicochemically the compounds acetylgenistin, acetylglycitin, and acetyldaidzin met Lipinski's Rule of Five criteria (BM (< 500), Log P (< 5), HBD (< 5), HBA (< 10), and MR (40-130)), pharmacokinetically the compound acetylgenistin met the ADME parameters and bioactively all six compounds had anticancer activity (Pa > 0.2). Based on the results of molecular docking analysis, the six soy isoflavone compounds can interact and have low binding energy values. The binding energy values of malonylgenistin, acetylgenistin, and acetyldaidzin are the lowest and close to trastuzumab, at -286.6, -283.4, and -277.7kcal/mol, respectively. These findings suggest that soybean (Glycine max L.) isoflavone compounds have potential as anticancer drug candidates in inhibiting HER2.
Co-Authors Karnasih, IGA Risda Amini Rofik Usman, Mohammad Shinta Mayasari Tri Agustin, Ayu