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All Journal Jurnal Jamu Indonesia Indonesian Journal of Jamu Clinical and Pharmaceutical Sciences Journal
Elina, Alifah Asri
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Other

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Optimization of Flocel 101 and Amylum as Fillers in Sambiloto (Andrographis paniculata (Burm.f.) Nees.) Capsules Formulation Kawiyanto, Joko; Elina, Alifah Asri; Heryatman, Siti Nashwa
Jurnal Jamu Indonesia Vol. 9 No. 3 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i3.336

Abstract

Sambiloto (Andrographis paniculata (Burm.f.) Nees.) is an herbal plant that is beneficial for health due to its main chemical component, andrographolide. Sambiloto can be formulated into capsules to make it more practical and comfortable for consumption, mask the bitter taste, and guarantee dosage accuracy. This research aimed to determine the optimal concentration of Flocel 101 and amylum as capsule fillers to achieve the best physical properties of Sambiloto extract capsules. The study was conducted experimentally using 5 (five) formulas (F1, F2, F3, F4, and F5) with various concentrations of Flocel 101 and amylum. A series of tests were conducted on the physical properties of the capsule powder: organoleptic tests, water content, flowability, disintegration time, and average capsule weight. Additionally, quality control was performed by checking for microbial contamination through total plate count (TPC) and yeast and mold count (YMC) tests. The results of this research indicated that the F1 formula provided the best physical properties and met the requirements, with the appearance of a greenish-gray dry powder, water content of 6.88%, flow rate of 20 g/s, disintegration time of 15.5 minutes, average weight of 0.55 g, TPC 250 cfu/g, and YMC <10 cfu/g.
The Effect of Starch-Lactose Filler Ratio on the Quality Characteristics of Meniran Extract Capsule Kawiyanto, Joko; Elina, Alifah Asri; Sasongko, Jessica Herlin Labella
Clinical and Pharmaceutical Sciences Journal Vol. 1 No. 1 (2025)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v1i1.313

Abstract

The empirical utilization of medicinal plants by Indonesians has long been known as "jamu". Meniran (Phyllanthus niruri Linn) is a plant containing phyllantin and hypophyllantin which have immunostimulant activity and potential for development into traditional medicine. This study aims to determine the influence of the starch-lactose filler ratio in the formulation of meniran extract herbal powder for the development of traditional medicine capsule preparations. The research was conducted experimentally using four meniran herbal powder formulas with variations in the starch-lactose filler ratio: 100%:0 (M1); 73%:27% (M2); 50%:50% (M3); and 27%:73% (M4). Based on the physicochemical properties of the powder, the most optimum formula was selected and evaluated for the quality of meniran extract capsule based on the requirements of the Indonesian Food and Drug Monitoring Agency, including organoleptic tests, flowability, loss on drying, and disintegration time. The results of this study show that variations in the starch-lactose filler ratio affect the moisture content of meniran herbal powder. Formula M2 with a starch:lactose filler ratio of 73:27 exhibited flowability that meets the requirements for development into traditional medicine capsules. Lactose at a concentration of 10% can be combined with starch as a filler and produce good loss on drying and disintegration time values.
Optimization of Flocel 101 and Amylum as Fillers in Sambiloto (Andrographis paniculata (Burm.f.) Nees.) Capsules Formulation Kawiyanto, Joko; Elina, Alifah Asri; Heryatman, Siti Nashwa
Jurnal Jamu Indonesia Vol. 9 No. 3 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i3.336

Abstract

Sambiloto (Andrographis paniculata (Burm.f.) Nees.) is an herbal plant that is beneficial for health due to its main chemical component, andrographolide. Sambiloto can be formulated into capsules to make it more practical and comfortable for consumption, mask the bitter taste, and guarantee dosage accuracy. This research aimed to determine the optimal concentration of Flocel 101 and amylum as capsule fillers to achieve the best physical properties of Sambiloto extract capsules. The study was conducted experimentally using 5 (five) formulas (F1, F2, F3, F4, and F5) with various concentrations of Flocel 101 and amylum. A series of tests were conducted on the physical properties of the capsule powder: organoleptic tests, water content, flowability, disintegration time, and average capsule weight. Additionally, quality control was performed by checking for microbial contamination through total plate count (TPC) and yeast and mold count (YMC) tests. The results of this research indicated that the F1 formula provided the best physical properties and met the requirements, with the appearance of a greenish-gray dry powder, water content of 6.88%, flow rate of 20 g/s, disintegration time of 15.5 minutes, average weight of 0.55 g, TPC 250 cfu/g, and YMC <10 cfu/g.
Co-Authors Heryatman, Siti Nashwa Kawiyanto, Joko Sasongko, Jessica Herlin Labella