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EVALUATING THE IMPACT OF ENDOCRINE-DISRUPTING CHEMICALS ON FERTILITY IN WILDLIFE: FROM AMPHIBIANS TO MAMMALS Kadhim, Sajjad Jawad; Sahib, Mohsin Abbas; Khlaif, Salam Mohammed; AL-Azzawi, Mustafa Kareem; Zubaidi, Nabaa Abbas
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.841

Abstract

Endocrine-disrupting chemicals are contaminants that interrelate with wildlife's endocrine systems, producing negative influences on reproductive health and growth. Industrial pollutants, medicines and pesticides are between the chemicals that have develop a main source of worry due to of their pervasiveness in the environment and capability to reason ecological damage. This study brings both present data on the effects of EDCs on reproductive health in a diversity of animal species, particularly birds, fish, frogs, and mammals. Amphibians, together their complex life cycles and pored skin are particularly susceptible to EDCs. In relation to studies, contact to chemicals such as atrazine able to damage sexual development, causing in slanted sex proportions and developmental irregularities. Fish, which are significant indicators of marine ecosystem health, exhibition changed sexual development and reproductive disappointments due to of EDCs like estrogenic compounds and PCBs. Birds are harmed via EDCs like DDT, which leading to reproductive failures and eggshell thinning, influencing general population health. Mammals, reaching from little rodents to enormous animals, developmental defects, display lower fertility and behavioral alterations in reply to EDC exposure. Such EDCs clearly and profoundly affect reproductive health via altering gene expression, blocking receptors and mimicking hormones. Studies provide wide-ranging insights for these pathways, while field investigations afford experimental evidence of the effects of EDCs. Bio-monitoring methods, like tissue analysis and health markers, are very important to determining exposure levels and results. Identifying the influence of EDCs on animal reproductive health is significant for conservation initiatives and emerging regulation. Effective regulations might contain limiting the usage of dangerous chemicals and establishing monitoring systems to checked EDC levels in environment and the animals. Conservation efforts must prioritize habitat management and refurbishment because offset the effects of EDCs and safeguard endangered species. This research confirms the requirement for ongoing research and work to address the issues presented via endocrine disruption in animal populations. The research will explore how toxic chemicals disturb nature reproduction via analyzing variations in mating habits, sexual development, and fertility. It will examine how these materials influence hormonal systems via inhibiting receptors and mimicking hormones. Additionally, the research will observe current legislation governing these chemicals, assess their effectiveness, and refer for greater animal protection.
Genetic Variability of Monkeypox Virus and Its Implications for Human Disease AL-Azzawi, Mustafa Kareem; Khlaif, Salam Mohammed; Zubaidi, Nabaa Abbas
International Journal Multidisciplinary (IJMI) Vol. 1 No. 3 (2024): International Journal Multidisciplinary (IJMI)
Publisher : Antis-Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/ijmi.v1i3.180

Abstract

The genomic sequencing of Monkeypox virus (MPXV) isolates has offered crucial insights into the virus's genetic variability and population biology. This review provides a concise summary of the current state of MPXV genetics and phylogenetics, with a particular emphasis on the potential of a broader dataset to improve molecular diagnostic methods and inform the development of antiviral medicines and diagnostic tests. The virus's evolutionary biology, particularly its interactions with natural reservoir hosts, can be better understood through the investigation of genetic data, precise outbreak identification, and improved surveillance. The genetic diversity among genotypes of monkeypox, a rare zoonotic infection with clinical manifestations similar to smallpox, significantly influences the severity of the disease and its transmission. The objective of this investigation is to enhance the genetic information on MPXV, evaluate the correlation between genotypic variations and disease outcomes, and investigate the manner in which these distinctions influence the pathogenesis of monkeypox. It is emphasized in the research that a multidisciplinary approach is crucial for the advancement of vaccine development, drug discovery, and the comprehension of virus-host interactions. The results underscore the necessity of ongoing genetic and serological surveillance to mitigate the obstacles presented by monkeypox and enhance public health responses.
EVALUATING THE IMPACT OF ENDOCRINE-DISRUPTING CHEMICALS ON FERTILITY IN WILDLIFE: FROM AMPHIBIANS TO MAMMALS Kadhim, Sajjad Jawad; Sahib, Mohsin Abbas; Khlaif, Salam Mohammed; AL-Azzawi, Mustafa Kareem; Zubaidi, Nabaa Abbas
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.841

Abstract

Endocrine-disrupting chemicals are contaminants that interrelate with wildlife's endocrine systems, producing negative influences on reproductive health and growth. Industrial pollutants, medicines and pesticides are between the chemicals that have develop a main source of worry due to of their pervasiveness in the environment and capability to reason ecological damage. This study brings both present data on the effects of EDCs on reproductive health in a diversity of animal species, particularly birds, fish, frogs, and mammals. Amphibians, together their complex life cycles and pored skin are particularly susceptible to EDCs. In relation to studies, contact to chemicals such as atrazine able to damage sexual development, causing in slanted sex proportions and developmental irregularities. Fish, which are significant indicators of marine ecosystem health, exhibition changed sexual development and reproductive disappointments due to of EDCs like estrogenic compounds and PCBs. Birds are harmed via EDCs like DDT, which leading to reproductive failures and eggshell thinning, influencing general population health. Mammals, reaching from little rodents to enormous animals, developmental defects, display lower fertility and behavioral alterations in reply to EDC exposure. Such EDCs clearly and profoundly affect reproductive health via altering gene expression, blocking receptors and mimicking hormones. Studies provide wide-ranging insights for these pathways, while field investigations afford experimental evidence of the effects of EDCs. Bio-monitoring methods, like tissue analysis and health markers, are very important to determining exposure levels and results. Identifying the influence of EDCs on animal reproductive health is significant for conservation initiatives and emerging regulation. Effective regulations might contain limiting the usage of dangerous chemicals and establishing monitoring systems to checked EDC levels in environment and the animals. Conservation efforts must prioritize habitat management and refurbishment because offset the effects of EDCs and safeguard endangered species. This research confirms the requirement for ongoing research and work to address the issues presented via endocrine disruption in animal populations. The research will explore how toxic chemicals disturb nature reproduction via analyzing variations in mating habits, sexual development, and fertility. It will examine how these materials influence hormonal systems via inhibiting receptors and mimicking hormones. Additionally, the research will observe current legislation governing these chemicals, assess their effectiveness, and refer for greater animal protection.