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All Journal JMGCB Indonesian Journal Health Science and Medicine Journal of Medical Genetics and Clinical Biology (JMGCB)
Abbas, Marwa Ismail
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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A COMPARATIVE STUDY OF THE QUALITATIVE CHANGES IN THE LEVELS OF IL-4 , IL-6 AND IL-10 AND THEIR RELATIONSHIP TO HEMATOLOGICAL PARAMETERS IN CHILDREN WITH E. VERMICULARIS INFECTION Abbas, Marwa Ismail; Abdulhasan, Rawaa Sahib; Farhan, Zainab Mohammed; A. mohsein, Osama
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.888

Abstract

Background; Enterobiasis (pinworm infection) caused by Enterobius vermicularis is a common parasitic infection prevalent worldwide especially in children. It causes many important symptoms and can lead to digestive problems and lead to malnutrition in children. Aims of the study; Knowing the relationship between levels of cytokine and the severity of infection in children and the extent of the impact of the infection on the child’s health in Iraq. Methodology; A Case-control study included 100 children suffering from infection with the worm E.vermicularis. The ages of the participants ranged from 3 to 10 years. The study included 50 healthy children matched in age and sex to the patient group. 5 ml of blood was collected from each participant at Al-Haboubi Teaching Hospital and at Nasiriyah General Hospital for the period between 3/1/2024 to 10/3/2024. CBC assay using a Sysmex device. Interleukins were examined using enzyme-linked immunosorbent assay. Result; The results showed that there was no statistical significance in age among the participants. While the results of WBC and CRP were significantly high in the patient group, in contrast to PCV and Hb which were significantly low. While interleukin 4 and interleukin 6 results showed a significant increase in the patient group, while interleukin 10 showed a significant decrease. Conclusions; High levels of biomarkers, indicate the immune response that causes by infection with the worm. Anemia due to the pathophysiology of inhibiting appetite and lack of absorption in Intestines for nutrients.
Inflammatory Biomarkers in Tissue Remodeling and Fibrosis Progression: Biomarker Inflamasi dalam Remodeling Jaringan dan Perkembangan Fibrosis Abbas, Marwa Ismail
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.120

Abstract

Background; Inflammatory biomarkers play a crucial role in tissue remodeling and fibrosis progression by mediating the inflammatory response and influencing extracellular matrix deposition. Aims of the study; Investigate the role of inflammatory biomarkers in tissue remodeling and the progression of fibrosis. Methodology; A case-control study of 90 patients, conducted from November 1, 2024, to February 1, 2025, aimed to examine the role of inflammatory biomarkers in tissue remodeling and fibrosis progression. The study included 60 patients diagnosed with fibrosis and 30 healthy controls. Blood samples were collected, processed, and analyzed for biomarkers (CRP, IL-6, IFN-γ, MCP-1, adiponectin) using ELISA. Fibrosis severity was assessed using FibroScan elastography and histopathology with Masson's trichrome stain to evaluate collagen deposition. These methods helped correlate systemic inflammatory biomarker levels with fibrosis progression. Result; The study showed no significant age difference between patients with tissue fibrosis (48.6 ± 10.4 years) and controls (47.2 ± 9.8 years, p = 0.52). However, patients had significantly higher BMI (27.8 ± 3.5 kg/m², p = 0.01) and a higher smoking rate (38%, p = 0.03). Inflammatory markers, including CRP, IL-6, IFN-γ, and MCP-1, were significantly elevated in patients. Adiponectin levels were lower (7.8 ± 1.9 μg/mL, p < 0.001). Strong correlations were found between inflammatory markers and fibrosis severity, with MCP-1 showing the strongest association. Conclusions; The study concluded that elevated inflammatory markers (CRP, IL-6, IFN-γ, MCP-1) and decreased adiponectin levels are strongly associated with tissue fibrosis progression. The inflammatory response, characterized by these biomarkers, promotes fibrosis through immune activation and tissue remodeling. Adiponectin's protective role against inflammation and fibrosis underscores its potential as a therapeutic target. Highlights: Biomarker Impact: Elevated CRP, IL-6, IFN-γ, and MCP-1 levels correlate with fibrosis severity. Protective Role: Lower adiponectin levels suggest its antifibrotic potential. Clinical Relevance: MCP-1 shows the strongest association, making it a key fibrosis indicator. Keyword: Inflammatory Biomarkers, Tissue Remodeling, Fibrosis Progression, CRP, Adiponectin, MCP-1
A COMPARATIVE STUDY OF THE QUALITATIVE CHANGES IN THE LEVELS OF IL-4 , IL-6 AND IL-10 AND THEIR RELATIONSHIP TO HEMATOLOGICAL PARAMETERS IN CHILDREN WITH E. VERMICULARIS INFECTION Abbas, Marwa Ismail; Abdulhasan, Rawaa Sahib; Farhan, Zainab Mohammed; A. mohsein, Osama
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.888

Abstract

Background; Enterobiasis (pinworm infection) caused by Enterobius vermicularis is a common parasitic infection prevalent worldwide especially in children. It causes many important symptoms and can lead to digestive problems and lead to malnutrition in children. Aims of the study; Knowing the relationship between levels of cytokine and the severity of infection in children and the extent of the impact of the infection on the child’s health in Iraq. Methodology; A Case-control study included 100 children suffering from infection with the worm E.vermicularis. The ages of the participants ranged from 3 to 10 years. The study included 50 healthy children matched in age and sex to the patient group. 5 ml of blood was collected from each participant at Al-Haboubi Teaching Hospital and at Nasiriyah General Hospital for the period between 3/1/2024 to 10/3/2024. CBC assay using a Sysmex device. Interleukins were examined using enzyme-linked immunosorbent assay. Result; The results showed that there was no statistical significance in age among the participants. While the results of WBC and CRP were significantly high in the patient group, in contrast to PCV and Hb which were significantly low. While interleukin 4 and interleukin 6 results showed a significant increase in the patient group, while interleukin 10 showed a significant decrease. Conclusions; High levels of biomarkers, indicate the immune response that causes by infection with the worm. Anemia due to the pathophysiology of inhibiting appetite and lack of absorption in Intestines for nutrients.
Co-Authors A. mohsein, Osama Abdulhasan, Rawaa Sahib Farhan, Zainab Mohammed