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All Journal JMGCB Journal of Medical Genetics and Clinical Biology (JMGCB)
D.K, Najmutdinova
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing

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IMPACT OF COVID-19 ON CARDIOVASCULAR COMPLICATIONS IN TYPE 2 DIABETES D.K, Najmutdinova; A, Urunbayeva D.; G, Sadikova N; A, Pulotova S
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.889

Abstract

Background: The COVID-19 pandemic, instigated by the SARS-CoV-2 virus, has precipitated unprecedented global health and economic challenges since its identification in late 2019. Specific Background: To date, over 770 million confirmed COVID-19 cases and millions of deaths have been documented worldwide. Individuals with Type 2 Diabetes Mellitus (T2DM) are particularly vulnerable, exhibiting an elevated risk of severe illness and mortality due to exacerbated inflammatory responses and frequent comorbidities such as cardiovascular disease, hypertension, and obesity. Knowledge Gap: Despite the known risks, the precise molecular interactions between SARS-CoV-2 and host cells, and how these may be modified by diabetes and its comorbidities, remain inadequately understood. Aims: This study aims to elucidate the molecular mechanisms underpinning the interaction between SARS-CoV-2 and human cells, with a specific focus on how T2DM influences these interactions. Results: Preliminary findings indicate that the presence of T2DM amplifies the inflammatory response to SARS-CoV-2 infection, likely through altered receptor interactions and exacerbated immune responses. Novelty: This research provides new insights into the differential impact of SARS-CoV-2 on diabetic versus non-diabetic patients, highlighting the role of diabetes-induced alterations in viral pathogenesis. Implications: Understanding these mechanisms is crucial for developing targeted therapeutic and preventive strategies to mitigate the heightened risk faced by individuals with T2DM during pandemics, thereby informing public health policies and clinical practices.
DIABETES MELLITUS AND COVID-19. CARDIOVASCULAR COMPLICATIONS AND COURSE OF TYPE 2 DIABETES MELLITUS AFTER CORONAVIRUS INFECTION D.K, Najmutdinova; D.A , Urunbayeva; N.G, Sadikova; S.A, Pulotova
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 9 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i9.906

Abstract

The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has had profound effects on global health and economics since its emergence in late 2019. Over 770 million confirmed cases of COVID-19 have been reported worldwide, with millions of deaths attributed to the virus. Studies have shown that individuals with T2DM are at a higher risk of severe illness and mortality if they contract COVID-19. The presence of diabetes, especially when poorly controlled, can exacerbate the inflammatory response to the virus. Patients with T2DM often have comorbidities such as cardiovascular disease, hypertension, and obesity, which further increase the risk of severe COVID-19 complications
IMPACT OF COVID-19 ON CARDIOVASCULAR COMPLICATIONS IN TYPE 2 DIABETES D.K, Najmutdinova; A, Urunbayeva D.; G, Sadikova N; A, Pulotova S
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.889

Abstract

Background: The COVID-19 pandemic, instigated by the SARS-CoV-2 virus, has precipitated unprecedented global health and economic challenges since its identification in late 2019. Specific Background: To date, over 770 million confirmed COVID-19 cases and millions of deaths have been documented worldwide. Individuals with Type 2 Diabetes Mellitus (T2DM) are particularly vulnerable, exhibiting an elevated risk of severe illness and mortality due to exacerbated inflammatory responses and frequent comorbidities such as cardiovascular disease, hypertension, and obesity. Knowledge Gap: Despite the known risks, the precise molecular interactions between SARS-CoV-2 and host cells, and how these may be modified by diabetes and its comorbidities, remain inadequately understood. Aims: This study aims to elucidate the molecular mechanisms underpinning the interaction between SARS-CoV-2 and human cells, with a specific focus on how T2DM influences these interactions. Results: Preliminary findings indicate that the presence of T2DM amplifies the inflammatory response to SARS-CoV-2 infection, likely through altered receptor interactions and exacerbated immune responses. Novelty: This research provides new insights into the differential impact of SARS-CoV-2 on diabetic versus non-diabetic patients, highlighting the role of diabetes-induced alterations in viral pathogenesis. Implications: Understanding these mechanisms is crucial for developing targeted therapeutic and preventive strategies to mitigate the heightened risk faced by individuals with T2DM during pandemics, thereby informing public health policies and clinical practices.
DIABETES MELLITUS AND COVID-19. CARDIOVASCULAR COMPLICATIONS AND COURSE OF TYPE 2 DIABETES MELLITUS AFTER CORONAVIRUS INFECTION D.K, Najmutdinova; D.A , Urunbayeva; N.G, Sadikova; S.A, Pulotova
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 9 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i9.906

Abstract

The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has had profound effects on global health and economics since its emergence in late 2019. Over 770 million confirmed cases of COVID-19 have been reported worldwide, with millions of deaths attributed to the virus. Studies have shown that individuals with T2DM are at a higher risk of severe illness and mortality if they contract COVID-19. The presence of diabetes, especially when poorly controlled, can exacerbate the inflammatory response to the virus. Patients with T2DM often have comorbidities such as cardiovascular disease, hypertension, and obesity, which further increase the risk of severe COVID-19 complications
Co-Authors A, Pulotova S A, Urunbayeva D. D.A , Urunbayeva G, Sadikova N N.G, Sadikova S.A, Pulotova