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All Journal JMGCB Journal of Medical Genetics and Clinical Biology (JMGCB)
Mahdi, Dawood S.
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing

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TOLL-LIKE (TLRS 1,4,5) IMMUNODETECTION OF SOME TOLL-LIKE RECEPTORS AS AN IMMUNE RESPONSE TO PATIENTS WITH ACUTE APPENDICITIS AND ITS EFFACT ON CLINICAL FEATURES IN BASRA/IRAQ shaker, Zainab Nihad; Mahdi, Dawood S.; Alsaimary, Ihsan Edan; Hoka, Saad Ishaq Iskandar
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 9 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i9.919

Abstract

Background: Acute Appendicitis is the most common cause of emergency cases worldwide, and it may have serious consequences. If there is no precise diagnosis, it poses a dreadful issue for the community. Researchers tried to use several markers to determine the definitive diagnosis of Appendicitis. Our research thus sought to determine the various Toll-like receptor TLR1, TLR4, and TLR5 concentrations in the blood of patients suspected of Appendicitis as a diagnostic predictor. Method: This study conducted a case-control analysis on patients diagnosed with Appendicitis in the operating room at Al-Sadr Teaching Hospital and Al-Shifaa Teaching Hospital in Basra, Iraq. The control group was randomly chosen between July 2023 and November 2023. a total of 88 samples were enrolled in the study. Seventy of these samples came from patients experiencing signs and symptoms of Appendicitis. In contrast, the remaining eighteen samples were collected from apparently healthy controls (AHC) who were identical to the patient's group in terms of age, gender, habitat, and other characteristics but did not experience any appendicitis symptoms. Ethical approval was obtained from the Basra Health Department for data collection. Results: According to the findings of this investigation, the immunological markers TLR1 and TLR4 were statistically significant at a level of (P≤0.05) between the serum samples of patients and the control groups. the median concentration of (TLR1 and TLR4) were (14.70 ,10.89 ng/ml) respectively than control group (8.15 ,6.98 ng/ml), statistically show highly significant (P-= 0.000), while the median concentration of TLR5 in appendicitis patients was lower (3.11 ng/ml) than control (3.77 ng\ml), without any significant differences (p=0.185). Conclusion: The serum concentration of TLR1 and TLR4 has the potential to predict the diagnosis of appendicitis.
TOLL-LIKE (TLRS 1,4,5) IMMUNODETECTION OF SOME TOLL-LIKE RECEPTORS AS AN IMMUNE RESPONSE TO PATIENTS WITH ACUTE APPENDICITIS AND ITS EFFACT ON CLINICAL FEATURES IN BASRA/IRAQ shaker, Zainab Nihad; Mahdi, Dawood S.; Alsaimary, Ihsan Edan; Hoka, Saad Ishaq Iskandar
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 9 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i9.919

Abstract

Background: Acute Appendicitis is the most common cause of emergency cases worldwide, and it may have serious consequences. If there is no precise diagnosis, it poses a dreadful issue for the community. Researchers tried to use several markers to determine the definitive diagnosis of Appendicitis. Our research thus sought to determine the various Toll-like receptor TLR1, TLR4, and TLR5 concentrations in the blood of patients suspected of Appendicitis as a diagnostic predictor. Method: This study conducted a case-control analysis on patients diagnosed with Appendicitis in the operating room at Al-Sadr Teaching Hospital and Al-Shifaa Teaching Hospital in Basra, Iraq. The control group was randomly chosen between July 2023 and November 2023. a total of 88 samples were enrolled in the study. Seventy of these samples came from patients experiencing signs and symptoms of Appendicitis. In contrast, the remaining eighteen samples were collected from apparently healthy controls (AHC) who were identical to the patient's group in terms of age, gender, habitat, and other characteristics but did not experience any appendicitis symptoms. Ethical approval was obtained from the Basra Health Department for data collection. Results: According to the findings of this investigation, the immunological markers TLR1 and TLR4 were statistically significant at a level of (P≤0.05) between the serum samples of patients and the control groups. the median concentration of (TLR1 and TLR4) were (14.70 ,10.89 ng/ml) respectively than control group (8.15 ,6.98 ng/ml), statistically show highly significant (P-= 0.000), while the median concentration of TLR5 in appendicitis patients was lower (3.11 ng/ml) than control (3.77 ng\ml), without any significant differences (p=0.185). Conclusion: The serum concentration of TLR1 and TLR4 has the potential to predict the diagnosis of appendicitis.
IMMUNOLOGICAL STUDY OF SOME BIOMARKER IN CELIAC DISEASE IN BASRAH PROVINCE Othafa, Duaa Faiz; Mahdi, Dawood S.; Al-Saimary, Ihsan Edan
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 1 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i1.1069

Abstract

Objective: This study investigates the diagnostic accuracy of IgG anti-deamidated gliadin peptide (DGP), IgA and IgG anti-tissue transglutaminase (tTG), IgG anti-gliadin (AGA), and IgG anti-endomysial antibodies (EMA) in diagnosing celiac disease (CD), particularly in patients with IgA deficiency. Methods: A case-control study was conducted with 118 participants, including 68 newly diagnosed CD patients and 50 healthy controls. Serum samples were collected and analyzed using the Sandwich-ELISA technique. Statistical analysis included chi-square tests, ANOVA, logistic regression, and Spearman correlation, using SPSS v26. Results: Antibody concentrations were significantly elevated in CD patients compared to controls (p = 0.0001). Median levels of anti-gliadin IgG, EMA IgG, DGP IgG, tTG IgA, and tTG IgG in patients were 40.8 ng/ml, 345.5 pg/ml, 11.5 nml/l, 2.85 ng/ml, and 95.5 ng/ml, respectively. Significant inverse correlations were observed between gliadin-IgG and EMA (-30.2%, p = 0.012), tTG IgA (-23.8%, p = 0.0001), and tTG IgG (-39.7%, p = 0.001). EMA demonstrated direct correlations with DPG (49%, p = 0.0001), tTG IgA (36.4%, p = 0.002), and tTG IgG (34.1%, p = 0.004). Novelty: This study highlights the diagnostic utility of IgG anti-DGP as a reliable marker in IgA-deficient populations and underscores the correlations among antibody markers, providing insights into their synergistic roles in CD diagnosis.
Co-Authors Al-Saimary, Ihsan Edan Alsaimary, Ihsan Edan Hoka, Saad Ishaq Iskandar Othafa, Duaa Faiz shaker, Zainab Nihad