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All Journal International Journal Multidisciplinary Journal of Medical Genetics and Clinical Biology (JMGCB)
Jabber , Ehab Y.
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Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics

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THE IMMUNOLOGICAL ROLE OF ANTI-H. PYLORI ANTIBODIES LEVEL, INF-Γ, AND TNF-Α IN A NUMBER OF PATIENTS WITH A TUMOR IN THE DIGESTIVE SYSTEM IN BABYLON GOVERNORATE Jaafar , Salim Shamkhi; Jabber , Ehab Y.; Alwish , Amer Abdul Husain; Al- Mammori , Raheem Tuama Obayes; Shareef , Hasanain Khaleel
International Journal Multidisciplinary (IJMI) Vol. 1 No. 3 (2024): International Journal Multidisciplinary (IJMI)
Publisher : Antis-Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/ijmi.v1i3.184

Abstract

General Background: Helicobacter pylori is a well-known bacterium responsible for chronic infections, significantly contributing to gastric and mucosa-associated lymphoid tissue cancers, as well as peptic ulcer disease. Specific Background: The link between H. pylori infection and gastrointestinal (GIT) tumors remains under-explored, particularly concerning immunological parameters. Knowledge Gap: The role of immune markers, such as anti-H. pylori IgG antibodies, TNF-α, and IFN-γ, in distinguishing between malignant and benign GIT tumors is unclear. Aims: This study aimed to assess the relationship between H. pylori infection and immunological factors in patients with malignant and benign GIT tumors, as well as controls, using serum levels of Anti-H. pylori IgG, TNF-α, and IFN-γ. Results: The study included 100 serum samples from patients with malignant (n=40) and benign (n=35) GIT tumors, irritable bowel disease (IBD) controls (n=15), and healthy controls (n=10). The results revealed significantly elevated levels of anti-H. pylori IgG in patients with malignant tumors compared to those with benign tumors, IBD controls, and healthy controls. Male patients had higher anti-H. pylori IgG levels than females. Elevated levels of TNF-α and IFN-γ were also observed in patients with malignant tumors, correlating with higher anti-H. pylori IgG levels. Novelty: This study highlights the association between elevated H. pylori IgG antibodies and increased TNF-α and IFN-γ levels in malignant GIT tumors, particularly in males, suggesting H. pylori's role in cancer progression. Implications: The findings suggest that early detection of elevated anti-H. pylori IgG and inflammatory cytokines could improve the diagnosis and management of GIT malignancies, especially in male populations. Further research on a larger cohort is recommended to explore the mechanisms driving this relationship.
REVIEW ARTICLE: BENEFICIAL BACTERIA AND THEIR EFFECT ON THE IMMUNE SYSTEM Jaafar, Salim Shamkhi; Jabber , Ehab Y.
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 8 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i8.1381

Abstract

Objective: This study aimed to show some of the commensal species in the parts of the digestive system and their role in developing the immune system and other functions and their positive effect on the health of the host. Method: Molecular investigations have shown the presence of single, if not dozens of trillions of species, nutrients, and host cells. Results: The commensal bacteria in the digestive system play an important role in modifying and developing the immune system, as they provide environmental requirements of nutrients that protect the mucosal lining of the intestine, which in turn is affected by mutual interactions with the microbes of the digestive system. Novelty: Thus, the digestive system is considered one of the most complex systems due to the continuous interaction between the enormous number of microorganisms.
Co-Authors Al- Mammori , Raheem Tuama Obayes Alwish , Amer Abdul Husain Jaafar , Salim Shamkhi Jaafar, Salim Shamkhi Shareef , Hasanain Khaleel