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Isbagio, H
Indonesian Rheumatology Association
Medicine & Pharmacology

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Predictor of joint damage in rheumatoid arthritis Sumariyono, Sumariyono; Isbagio, H
Indonesian Journal of Rheumatology Vol 2, No 2 (2010)
Publisher : Indonesian Rheumatology Association

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Abstract

Objective: This study was implemented to determine the joint damage predictor in rheumatoid arthritis (RA).Methods: A cross-sectional study was conducted on outpatients of the rheumatology clinic at Cipto Mangunkusumo General Hospital who had suffered from RA for more than 2 years during the period from October 1, 1999 to June 30, 2000. During this period, we obtained 23 RA patients who fulfi lled the inclusion and exclusion criteria. We evaluated the patients’ medical data that included gender, education, age of onset, rheumatoid factor (RF), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). Then we carriedout examinations and tests including X-ray of hand and wrist joints, RF, CRP, and ESR. The degree of joint damage was evaluated using the Larsen score.Results: Twenty three patients—all women, mean age of onset was 36.7 years, mean duration of disease was 62.8 months, educational level with high school degree or above were found in 19 cases (82.6%), and RF (+) at initial treatment were found in 10 cases (43.5%). The mean ESR at initial treatment was 77.9 mm/hr and CRP at initial treatment was between 0 and 768 mg/dL. The Larsen score ranged between 0 and 68 with a meanof 21.7. In bivariate analysis, the Larsen score was signifi cantly higher in the group with positive RF at initial treatment compared to that in the group with negative RF at initial treatment (p = 0.031). C-reactive protein and ESR at initial treatment and the age of onset did not have any signifi cant correlation with the Larsen score, but there was a signifi cant correlation of CRP and ESR during the study with the the Larsen score.Conclusion: RF level was the most signifi cant predictor in determining the degree of joint damage according to the Larsen score while initial positive RF had lower signifi cance level.
Correlation of serum level of interleukin-6 and disease activity with bone-resorption activity in premenopausal rheumatoid arthritis patients Akil, Natsir; Isbagio, H; Sumariyono, Sumariyono
Indonesian Journal of Rheumatology Vol 4, No 1 (2013)
Publisher : Indonesian Rheumatology Association

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Background: Rheumatoid arthritis (RA) is a chronic, systemic disease characterized by inflammation and cellular proliferation in the synovial lining of joints that can ultimately result in cartilage and bone destruction.Patients with RA are at increased risk of osteoporotic fractures in both axial and appendicular bones. Several cytokines are involved in the pathogenesis of osteoporotic RA patients, including tumor necrosis factor α, interleukin (IL)-1, IL-6, and IL-17. Among these cytokines, IL-6 has a pivotal role in the pathogenesis of increased bone resorption in postmenopausal RA patients. There are currently scarce data concerning this process in premenopausal RA patients.Objective: To determine the correlation of serum level IL-6 and disease activity with bone-resorption activity in premenopausal RA patients. Methods: This is a cross-sectional study with consecutive sampling method conducted at the Division of Rheumatology, Cipto Mangunkusumo General Hospital from June until August 2010. Bone-resorption activity was quantified using serum C-terminal crosslinking telopeptide of type I collagen (CTx-I) level, while disease activity was assessed using the 28-joint disease activity (DAS28) score. Statistical analysis was performed to investigate the correlation of serum IL-6 level and disease activity with serum CTx-I level.Results: There were 38 patients enrolled in this study. Mean serum level of IL-6 was 10.99 pg/mL (SD 16.06). Mean serum level of CTx-I was 405.37 pg/mL (SD 199.32). There was no significant correlation (p = 0.252) between serum IL-6 level with serum CTx-I level;however, a significant correlation existed (r = 0.389, p = 0.033) among seropositive patients. There was no significant correlation (p = 0.257) between the DAS28score with serum CTx-I level.Conclusion: There were no significant correlation either of serum IL-6 level or disease activity with serum CTx-I level among patients in this study
Risk factors of osteoarthritis that reduce the Steinbrocker’s functional capacity of patients with osteoarthritis of the knee Setiyohadi, Bambang; Nasution, A R; Isbagio, H
Indonesian Journal of Rheumatology Vol 1, No 1 (2009)
Publisher : Indonesian Rheumatology Association

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Abstract

Objective. This study was implemented to determine the risk factors of osteoarthrosis which potentially could reduce the Steinbrocker’s functional capacity (SFC) of patients with osteoarthrosis of the knee.Method. In this cross sectional study, the cases were taken consecutively from the ambulatory patient with the osteoarthrosis of the knee who visited the rheumatologyclinic, Cipto Mangunkusumo Hospital. Subjects was interviewed to record the existing and severity risk factors using a structured questionnaire regarding their age, gender, duration of the illness pattern of smoking history of diabetes mellitus, menopause, body mass index (BMI), knee joint deformity, 15 meters walking time and KellgrenLawrence radiologic index.Results. One hundred thirteen cases of osteoarthrosis of the knee were assigned to the study between July to December 1992, 24 patients were male and 89 werefemale. Eighteen patients were designated to SFC I, 77 patients to SFC II, 14 patients to SFC III and 4 patients to SFC IV. With the logistic regression analysis, it was found that the signifi cant risk factors of developing SFC II, III and IV from patients of SFC I were being female and smoking. In the second logistic regression analysis we found that the signifi cant risk factors for developing SFC III and IV from patients of SFC I and II were age and BMI.Conclusion. In this study we have found that age, smoking, female genders, and BMI were the risk factors which potentially could reduce the SFC of patients withosteoarthrosis of the knee.
Co-Authors Akil, Natsir Bambang Setiyohadi Nasution, A R Sumariyono Sumariyono