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All Journal Majalah Kedokteran Nusantara The Journal Of Medical School
Sastrodiningrat, Abdul Gofar
Fakultas Kedokteran USU
Health Professions Medicine & Pharmacology

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Analisis Kadar Glial Fibrillary Acidic Protein dengan Tingkat Keparahan Cedera Kepala di Rumah Sakit Umum Pusat (RSUP) Haji Adam Malik Sinulingga, R. Disfahan Yonanda; Japardi, Iskandar; Sastrodiningrat, Abdul Gofar
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 50, No 3 (2017): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Introduction This study was to determine the relationship of serum Glial Fibrillary Acidic Protein (GFAP) levels with severity of head injury patients.Methods This study was an analytical study using cross-sectional design. The study lasted from June 2013 until March 2014 at Adam Malik General Hospital. Severe head injury patients were included in the study if the onset is less than 48 hours. Selected patients were evaluated based on the findings of the Computed Tomography (CT) scan of the head. Consecutive sampling was done to select the subjects, then blood samples were taken for examination and imeasurement of cumulative GFAP serum level.Results The results showed that GFAP levels were associated significantly with GCS after resuscitation (r = -0.631, p = 0.0001). The correlation was a negative correlation (r = -0.631, p = 0.0001). If the higher Glasgow Coma Scale (GCS) after resuscitation, serum GFAP levels would be even lower.Conclusion Levels of GFAP severe head injury patients (11.9 ± 10.52) was significantly higher compared to patients with moderate head injury (1.82 ± 1.60, p = 0.0001). There is a significant correlation between serum GFAP levels with initial GCS after resuscitation (r = -0.631, p = 0.0001).Keywords : GFAP, head injury, biomarker
Gambaran pewarnaan imunohistokimia S100 pada meningioma di Rumah Sakit Umum Pusat H. Adam Malik Medan Gatot Aji Prihartomo; Abdul Gofar Sastrodiningrat; Iskandar Japardi; Sufida dr
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 46, No 1 (2013): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Introduction: This study explores and describe the S100 immunohistochemical staining in meningioma.Methods: Sample specimens collected from patients who had meningioma undergo tumor removal surgery in the Adam Malik General Hospital Medan has previously been carried out basic hematoxylin eosin staining and was confirmed as meningioma by Epithelial Membrane Antigene (EMA) imunohystochemical staining. Representative slides are made of paraffin blocks and then performed S100 immunohistochemical staining. Staining intensity (SI) was score on scale 0-3 (from no staining to strong staining). Then viewed the characteristics of gender, age, location of tumor, World Health Organization (WHO) meningioma grade, histopathologictype, and tumor recurrence of meningioma specimens that express S100 immunohistochemical staining.Results: Thirty-one specimens of meningioma classified according to WHO criteria: benign 28/31 (90.3%), atypical 2/31 (6.5%) and anaplastic 1/31 (3.2%). These three criteria are classified according to histopathologic type. Meningothelial meningioma is the most widely histopathological types 17/31 (54.8%). Of the overall sample specimens, only 11/31 (35.5%) specimens expressed S100 immunohistochemical staining, the remaining 20/31 (64.5%) did not express. Of the 11 specimens that express S100 staining, benign meningiomas express 8/28 (28.6%) and fibroblastic meningiomas are the most strong S100 immunohistochemical staining( +3) between all the histopathologic type.Conclusion: In general, the results obtained from this study correspond by previous literature.Keyword: immunohistochemical staining; S100; meningioma
Co-Authors Gatot Aji Prihartomo Iskandar Japardi Iskandar Japardi Sinulingga, R. Disfahan Yonanda Sufida dr