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All Journal JSFK (Jurnal Sains Farmasi & Klinis)
Adhitya Jessica
Universitas Andalas
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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A Novel Postbiotic Patch Formulation Using Pediococcus acidilactici BK01 for Anti-Acne Applications Lidia Armayeni; Rini Agustin; Sri Melia; Adhitya Jessica
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.70-83.2026

Abstract

Acne is an inflammatory skin disorder often associated with infection by Cutibacterium acnes. Postbiotics in the form of cell-free supernatant (CFS) from Pediococcus acidilactici BK01 contain lactic acid, bacteriocins, and hydrogen peroxide, which exhibit potential antibacterial activity. This study aimed to formulate P. acidilactici BK01 CFS into a topical patch and evaluate its activity against C. acnes. Antibacterial activity and minimum inhibitory concentration (MIC) were determined using the well-diffusion method. The MIC (6.25%) was used to formulate patches via solvent-casting with HPMC K4M or PVA (2–4%) as polymers and glycerin, propylene glycol, or PEG 400 (0.2–0.6%) as plasticizers. The selected formulation was evaluated for antibacterial activity and physical characteristics. A combination of 4% PVA and 0.6% glycerin produced the best base and was used to prepare patches containing 6.25–75% CFS. The 65% CFS patch showed the highest inhibition against C. acnes ATCC 11827 (12.03 ± 0.373 mm), categorized as strong. The patch demonstrated acceptable organoleptic properties, thickness, folding endurance, pH, moisture content, and tensile strength. These findings indicate that the 65% CFS patch has potential as a topical anti-acne preparation.
Rapid Release ODF Loaded with Ketoprofen– Tromethamine Multicomponent Crystals: Formulation and Evaluation Indah Syahrani; Adhitya Jessica; Erizal Zaini
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.90-100.2026

Abstract

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) with low solubility and limited bioavailability. To enhance its solubility, ketoprofen was modified into a multicomponent crystal with tromethamine using the solvent evaporation method. The ketoprofen–tromethamine multicomponent crystal was then formulated into an orally dissolving film (ODF) to produce a dosage form that rapidly disintegrates in the oral cavity. The ODF was prepared by the solvent casting method, with variations in HPMC K4M as the film-forming polymer and PEG 400, propylene glycol, and glycerin as plasticizers. The formulations were evaluated based on organoleptic properties, thickness, pH, folding endurance, moisture content, swelling index, disintegration time, and dissolution profile. The optimal formulation was identified in F07, which consisted of 2% HPMC K4M and 30% PEG 400, resulting in a film with the best physical and mechanical properties and a disintegration time of 37.21 ± 1.93 seconds. These findings indicate that the ketoprofen–tromethamine multicomponent crystal ODF improves dissolution performance and meets the criteria for fast-disintegrating dosage forms, suggesting its potential as an effective alternative for patients with swallowing difficulties.
Co-Authors Erizal Zaini Indah Syahrani Lidia Armayeni Melia, Sri Rini Agustin