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Tağtekin, Dilek
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Dentistry

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The Biocompatibility of a Ginger-Containing Herbal Toothpaste on Developing Zebrafish Embryos Meseli, Simge; Ustundag, Unsal Veli; Ates, Perihan Seda; Unal, Ismail; Alturfan, Ebru Isik; Tağtekin, Dilek; Yanikoglu, Funda
Journal of Dentistry Indonesia Vol. 30, No. 2
Publisher : UI Scholars Hub

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The biocompatibility of toothpaste in an oral cavity should be approved by clinical trials. Nowadays, herbal toothpaste is increasing in popularity due to its natural ingredients. Being genetically similar to humans, zebrafish are used in potential toxicity testing. The zebrafish embryotoxicity test is a fast and straightforward method to study chemical toxicity during embryogenesis. Objective: This study aimed to evaluate if there was any biocompatibility of the toothpaste on zebrafish embryos. Methods: Adult AB strain zebrafish were used according to Institutional Animal Care and Use Committee protocols. Normally dividing, spherical embryos were exposed to herbal toothpaste with ginger (Gumgumix, Turkey) (50 mg/L) and conventional toothpaste (Signal, Expert Protection, Bulgaria) (50 mg/L) in well plates containing 20 embryos, having four replicates. Developmental effects, mortality, and hatching rates were evaluated for 72h. Results: Zebrafish embryos exposed to conventional toothpaste had a higher mortality rate than those exposed to herbal toothpaste; they hatched later and delayed in development. There was no difference between herbal toothpaste and the control group regarding mortality and hatching rates (p > 0.005). Conclusion: The herbal toothpaste showed higher biocompatibility on zebrafish embryos compared to the conventional toothpaste under the condition of this study.
Comparison of Two Different Intraoral Scanners for Determination of Caries Related Volume Loss in Caries Removal Şeker, Merve; Alkan, Elif; Tağtekin, Dilek; Korkut, Bora; Yanıkoğlu, Funda
Journal of Dentistry Indonesia Vol. 30, No. 2
Publisher : UI Scholars Hub

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Abstract

Objective: The study aimed to compare cavity volume data obtained with two different intraoral scanners. Methods: One hundred extracted molar teeth were divided into groups according to ICDAS-II classification, and scanned with Cerec Omnicam (Dentsply Sirona) and iTero Element Flex (Align Technology). The caries-infected tissues were removed regarding either minimally invasive or conventional cavity principles. Samples were scanned again and volumetric data were assessed by Meshmixer 3.5 (Autodesk) 3D modeling software. Statistical evaluations were performed with Mann Whitney U test and Spearman’s Correlation test. The significance level was α=0.05. Results: Although there was a significant difference between obtained initial volume readings of two scanners for 3M and 3C groups (p < 0.05), no significant difference was observed among other groups (p ≥ 0.05). Regarding the comparison of final volume readings of two scanners, a significant difference was found for 5M group (p = 0.036), whereas no significant difference was observed for other groups (p ≥ 0.05). Percentage of volume loss between two scanners was statistically similar (p ≥ 0.05). Conclusion: Data obtained with Cerec Omnicam and iTero Element Flex were compatible with volumetric assessments. Both intraoral scanners may be considered effective for calculating caries-related cavity volumes. Minimally invasive cavity principles may provide less volume loss compared to conventional cavity principles.
Co-Authors Alkan, Elif Alturfan, Ebru Isik Ates, Perihan Seda Korkut, Bora Meseli, Simge Şeker, Merve Unal, Ismail Ustundag, Unsal Veli Yanikoglu, Funda