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All Journal JOURNAL OF BIOMEDICAL SCINECES AND HEALTH
Anwar Rovik
Universitas Gadjah Mada
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : JOURNAL OF BIOMEDICAL SCINECES AND HEALTH

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Ethnobotany and Potential of Suruhan (Peperomia pellucida) as a Herbal Medicine Ingredient Anwar Rovik; Vania Uly Andyra; Laelatul Afifah; Nur Rokhmalia
Journal Of Biomedical Sciences and Health Vol. 1 No. 1 (2024): Bulan Februari 2024
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/718g9w21

Abstract

People have long used various herbs for traditional medicine. One of the medicinal plants used by local people is suruhan or sirih cina (Peperomia pellucida). Peperomia pellucida has many local names, such as suruhan, sirih cina, rumput cacing, sirih bumi, pansit-pansitan, rumput gelas, and daing siheah cino. Suruhan plants are used in traditional medicine in various ways, depending on the type of disease. The most widely used part of the plant is the leaves. Suruhan contains many bioactive compounds, such as alkaloids, flavonoids, sterols, tannins, reducing sugars, amino acids, saponins, triterpenoids, carbohydrates, phenols, azulene, carotenoids, and quinones. Suruhan has the potential as an herbal medicinal, including antimicrobe, anticancer, and antifungal.
ANTIBACTERIAL ACTIVITY OF RED GINGER (Zingiber officinale var. rubrum) EXTRACTS AS GROWTH INHIBITORS OF Klebsiella pneumoniae Anwar Rovik
Journal Of Biomedical Sciences and Health Volume 1 No. 2 Agustus 2024
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/

Abstract

Pneumonia, a significant global health concern, is caused by Klebsiella pneumoniae infection. Antibiotic use is the primary treatment for K. pneumoniae infection; however, inappropriate use of antibiotics can result in bacterial resistance. Antimicrobial resistance poses a significant challenge in treating K. pneumoniae infections, as it can render existing antibiotics ineffective against infections. Natural products derived from plants have received considerable attention as potential sources of new antimicrobial agents, including red ginger (Zingiber officinale var rubrum). This study aims to determine red ginger extracts' effectiveness in inhibiting the growth of Klebsiella pneumoniae in vitro and silico. The research stages included compound extraction from red ginger rhizomes, antimicrobial activity testing against K. pneumoniae, and in silico analysis of target genes. The red ginger extract inhibited the growth of K. pneumoniae. The 25% extract concentration gave the most minor inhibition, with an inhibition zone of 6.7 mm. The 100% extract concentration gave the most significant inhibition, with an inhibition zone of 8 mm. The bioactive compound of red ginger may target various proteins and act in multiple sites in K. pneumoniae cells. This study showed that red ginger targets the acrR gene, a multidrug efflux pump AcrAB operon transcription repressor essential in the resistance of K. pneumoniae to antibiotics. Keywords: antimicrobial resistance; efflux pump; Klebsiella pneumoniae; red ginger Pneumonia masih menjadi masalah kesehatan global yang signifikan, disebabkan oleh infeksi Klebsiella pneumoniae. Penggunaan antibiotik adalah pengobatan utama untuk infeksi K. pneumoniae; namun, penggunaan antibiotik yang tidak tepat dapat menyebabkan resistensi bakteri. Resistensi antimikroba merupakan tantangan yang signifikan dalam mengobati infeksi K. pneumoniae, karena dapat membuat antibiotik yang ada menjadi tidak efektif melawan infeksi. Produk alami yang berasal dari tanaman telah mendapat perhatian yang cukup besar sebagai sumber potensial agen antimikroba baru, termasuk jahe merah (Zingiber officinale var rubrum). Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak jahe merah dalam menghambat pertumbuhan Klebsiella pneumoniae in vitro dan in silico. Tahapan penelitian meliputi ekstraksi senyawa dari rimpang jahe merah, pengujian aktivitas antimikroba terhadap K. pneumoniae, dan analisis in silico gen target. Ekstrak jahe merah menghambat pertumbuhan K. pneumoniae. Konsentrasi ekstrak 25% memberikan daya hambat yang paling kecil, dengan zona hambat sebesar 6,7 mm. Konsentrasi ekstrak 100% memberikan daya hambat yang paling besar, dengan zona hambat sebesar 8 mm. Senyawa bioaktif jahe merah dapat menargetkan berbagai protein dan bekerja di berbagai tempat dalam sel K. pneumoniae. Hasil penelitian menunjukkan bahwa ekstrak jahe merah menargetkan gen acR, sebuah multidrug efflux pump AcrAB operon transcription repressor yang berperan penting dalam resistensi K. pneumoniae terhadap antibiotik. Kata kunci: jahe merah; Klebsiella pneumoniae; pompa eflux; resistensi antimikroba
Co-Authors Laelatul Afifah Nur Rokhmalia Vania Uly Andyra