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All Journal JRST (Jurnal Riset Sains dan Teknologi) Jurnal Tumbuhan Obat Indonesia Journal of Biomedical Sciences and Health
Anwar Rovik
Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Engineering Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Network Analysis Reveals Tea Catechins as Multi-Target Inhibitors of Colon Adenocarcinoma Anwar Rovik; Dyah Fitri Kusharyati
JRST (Jurnal Riset Sains dan Teknologi) Volume 9 No. 2 September 2025: JRST
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/jrst.v9i2.23742

Abstract

Colon cancer is the second most common cause of cancer death worldwide. It drives the need for effective prevention and treatment strategies, including identifying new and inventive targets for treating colon cancer. This present study evaluated the potential of tea catechins against colon adenocarcinoma in silico. The study method includes a literature review, an analysis of protein targets and protein interactions, and network analysis. The prediction analysis showed that only epicatechin-3-gallate, epigallocatechin-3-gallate, and epigallocatechin potentially target colon cancer. These compounds target six common proteins in human cancer cells, such as AURKA, CA9, SERPINE1, MET, SQLE, and VEGFA. The analysis showed that the protein targets interact strongly with various proteins in human cancer cells. Therefore, tea catechin, especially epigallocatechin-3-gallate, can be explored as a colon cancer chemopreventive agent.
Network Pharmacology and Molecular Docking Analysis of Fagonia cretica Compounds as Chemopreventive Agents in Luminal Breast Cancer Eman Jehangir; Afifah Nur Rizqi; Syedah Ruqayyah Hadiyah; Anwar Rovik
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 2 (2025): December 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i2.3275

Abstract

Breast cancer remains a public health issue. In Pakistan, breast cancer cases continue to rise annually.Tamoxifen is a standard treatment for patients with luminal breast cancer (ER+); however, prolong use oftamoxifen cause side effects and may lead to drug resistance. Therefore, there is an urgent need to explorenatural compounds as safer chemopreventive agents. This study uses computational methods to investigatecompounds from Fagonia cretica and their potential interactions with molecular targets relevant to luminalbreast cancer. We combined a literature review, network pharmacology, and molecular docking to identifypromising therapeutic agents from Fagonia cretica. The plant contains various natural compounds, mainlyfound in its aerial parts. Several compounds are frequently reported, including isorhamnetin, oleanolic acid,gallic acid, kaempferol, and apigenin. These compounds meet favorable drug-like characteristics. Networkpharmacology analysis indicated that these compounds target several key cancer-related proteins andpathways, including CA12, AURKB, CDK1, PLK1, MMP9, NEK2, TOP2A, CCNB1, CCNB2, and ESR1.Kaempferol exhibited good binding affinities in molecular docking simulations for key protein targets: CDK1(-7.39 kcal/mol), ESR1 (-7.73 kcal/mol), and MMP9 (-7.29 kcal/mol). Our findings suggest that Fagoniacretica has potential as a multitarget chemopreventive agent in luminal breast cancer. Keywords: breast cancer, ethnomedicine, Fagonia cretica, targeted therapy
Multitarget Therapeutic Potential of Mimosa pudica (Linn.) in Luminal-Type Breast Cancer: A Bibliometric, Network Pharmacology, and Molecular Docking Analysis Anwar Rovik; Laelatul Afifah; Vania Uly Andyra
Jurnal Tumbuhan Obat Indonesia Vol. 19 No. 1 (2026): July 2026
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v19i1.3150

Abstract

The growing burden of breast cancer and the limitations of current treatment strategies underscore theneed to identify alternative therapeutic approaches. This study investigated the multitarget therapeuticpotential of Mimosa pudica (Linn.) against luminal-type breast cancer using an integrated computationalframework that combined bibliometric analysis, drug-likeness and ADMET screening, networkpharmacology, gene expression analysis, and molecular docking. Bioactive compounds reported from M.pudica were evaluated in silico to assess physicochemical characteristics, pharmacokinetic properties, andpotential molecular targets. Predicted protein targets were further analyzed using protein–proteininteraction network analysis and visualized in Cytoscape to identify key pathways associated with breastcancer progression. The analysis identified multiple candidate compounds with favorable pharmacologicalprofiles and predicted interactions with proteins involved in critical biological processes, including cellcycle regulation, DNA metabolism, growth factor signaling, angiogenesis, migration, and invasion. Networkanalysis highlighted several hub proteins associated with luminal-type breast cancer, among which AURKAand CDK1 were prioritized for molecular docking based on network topology, pathway enrichment,biological relevance, and structural suitability. Molecular docking demonstrated favorable predictedinteractions between selected flavonoids—apigenin, galangin, kaempferol, diosmetin, and chrysin—andboth target proteins, with binding energies ranging from −7.6 to −8.9 kcal/mol. These ????indings providemechanistic insight into the potential molecular actions of M. pudica-derived compounds and support theirprioritization as candidate therapeutic molecules for further experimental investigation in luminal-typebreast cancer. Keywords: bibliometrics; luminal-type breast cancer; Mimosa pudica; molecular docking; multitargettherapy; network pharmacology
ANTIBACTERIAL ACTIVITY OF RED GINGER (Zingiber officinale var. rubrum) EXTRACTS AS GROWTH INHIBITORS OF Klebsiella pneumoniae Anwar Rovik
Journal of Biomedical Sciences and Health Vol. 1 No. 2 (2024)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v1.i2.85

Abstract

Pneumonia, a significant global health concern, is caused by Klebsiella pneumoniae infection. Antibiotic use is the primary treatment for K. pneumoniae infection; however, inappropriate use of antibiotics can result in bacterial resistance. Antimicrobial resistance poses a significant challenge in treating K. pneumoniae infections, as it can render existing antibiotics ineffective against infections. Natural products derived from plants have received considerable attention as potential sources of new antimicrobial agents, including red ginger (Zingiber officinale var rubrum). This study aims to determine red ginger extracts' effectiveness in inhibiting the growth of Klebsiella pneumoniae in vitro and silico. The research stages included compound extraction from red ginger rhizomes, antimicrobial activity testing against K. pneumoniae, and in silico analysis of target genes. The red ginger extract inhibited the growth of K. pneumoniae. The 25% extract concentration gave the most minor inhibition, with an inhibition zone of 6.7 mm. The 100% extract concentration gave the most significant inhibition, with an inhibition zone of 8 mm. The bioactive compound of red ginger may target various proteins and act in multiple sites in K. pneumoniae cells. This study showed that red ginger targets the acrR gene, a multidrug efflux pump AcrAB operon transcription repressor essential in the resistance of K. pneumoniae to antibiotics. Keywords: antimicrobial resistance; efflux pump; Klebsiella pneumoniae; red ginger Pneumonia masih menjadi masalah kesehatan global yang signifikan, disebabkan oleh infeksi Klebsiella pneumoniae. Penggunaan antibiotik adalah pengobatan utama untuk infeksi K. pneumoniae; namun, penggunaan antibiotik yang tidak tepat dapat menyebabkan resistensi bakteri. Resistensi antimikroba merupakan tantangan yang signifikan dalam mengobati infeksi K. pneumoniae, karena dapat membuat antibiotik yang ada menjadi tidak efektif melawan infeksi. Produk alami yang berasal dari tanaman telah mendapat perhatian yang cukup besar sebagai sumber potensial agen antimikroba baru, termasuk jahe merah (Zingiber officinale var rubrum). Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak jahe merah dalam menghambat pertumbuhan Klebsiella pneumoniae in vitro dan in silico. Tahapan penelitian meliputi ekstraksi senyawa dari rimpang jahe merah, pengujian aktivitas antimikroba terhadap K. pneumoniae, dan analisis in silico gen target. Ekstrak jahe merah menghambat pertumbuhan K. pneumoniae. Konsentrasi ekstrak 25% memberikan daya hambat yang paling kecil, dengan zona hambat sebesar 6,7 mm. Konsentrasi ekstrak 100% memberikan daya hambat yang paling besar, dengan zona hambat sebesar 8 mm. Senyawa bioaktif jahe merah dapat menargetkan berbagai protein dan bekerja di berbagai tempat dalam sel K. pneumoniae. Hasil penelitian menunjukkan bahwa ekstrak jahe merah menargetkan gen acR, sebuah multidrug efflux pump AcrAB operon transcription repressor yang berperan penting dalam resistensi K. pneumoniae terhadap antibiotik. Kata kunci: jahe merah; Klebsiella pneumoniae; pompa eflux; resistensi antimikroba
Co-Authors Afifah Nur Rizqi Dyah Fitri Kusharyati Eman Jehangir Laelatul Afifah Laelatul Afifah Nur Rokhmalia Syedah Ruqayyah Hadiyah Vania Uly Andyra Vania Uly Andyra