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All Journal JRST (Jurnal Riset Sains dan Teknologi)
Anwar Rovik
Universitas Gadjah Mada
Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Engineering

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Network Analysis Reveals Tea Catechins as Multi-Target Inhibitors of Colon Adenocarcinoma Anwar Rovik; Dyah Fitri Kusharyati
JRST (Jurnal Riset Sains dan Teknologi) Volume 9 No. 2 September 2025: JRST
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/jrst.v9i2.23742

Abstract

Colon cancer is the second most common cause of cancer death worldwide. It drives the need for effective prevention and treatment strategies, including identifying new and inventive targets for treating colon cancer. This present study evaluated the potential of tea catechins against colon adenocarcinoma in silico. The study method includes a literature review, an analysis of protein targets and protein interactions, and network analysis. The prediction analysis showed that only epicatechin-3-gallate, epigallocatechin-3-gallate, and epigallocatechin potentially target colon cancer. These compounds target six common proteins in human cancer cells, such as AURKA, CA9, SERPINE1, MET, SQLE, and VEGFA. The analysis showed that the protein targets interact strongly with various proteins in human cancer cells. Therefore, tea catechin, especially epigallocatechin-3-gallate, can be explored as a colon cancer chemopreventive agent.
Co-Authors Dyah Fitri Kusharyati Laelatul Afifah Nur Rokhmalia Vania Uly Andyra