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Muhammad Chairul
Universitas Prima Indonesia
Aerospace Engineering Computer Science & IT Health Professions Medicine & Pharmacology Neuroscience Nursing Social Sciences

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Comparison Of Post-Cesarean Section Pain Medication With Spinal Anesthesia Method Eracs And Without ERACS Boyke Marthin Simbolon; Thoriq Akrom; Muhammad Chairul
Eduvest - Journal of Universal Studies Vol. 4 No. 11 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i11.49923

Abstract

This study focused on the observation of pregnant women after surgery to determine the comparison of drugs and pain scales after surgery with the ERACS method and the method without ERACS. This study aims to determine the comparison of drugs and pain scales in patients after Sectio Caesarea surgery using the ERACS method and without ERACS. Currently, the Enhanced Recovery After Caesarian Surgery (ERACS) method as a perioperative program is popular, because it is considered to have a faster healing time and minimize pain so as to provide comfort to patients. This quantitative study was designed using a Cross-Sectional approach. The research sample was 40 respondents whose Pain Scale was measured using the Visual Analog Scale (VAS) measured with an observation sheet. Based on the results of statistical analysis. In the results of the Univariate test analysis on drug administration and pain scales of both VAS variables after (24 hours). It can be concluded that there is a difference between the amount of pain medication given and the pain scale with the ERACS method and the method without ERACS. The ERACS method has been shown to be more effective in reducing pain after Sectio Caesarea surgery and accelerating patient recovery compared to the method without ERACS. These findings support the use of the ERACS method as a standard of care to improve patient comfort and clinical efficiency
Efektivitas Krim Nanoemulsi Ekstrak Daun Mangkokan (Nothopanax Scutellarium) Dalam Penyembuhan Luka dan Pertumbuhan Rambut Pada Tikus Wistar Diabetes yang Diinduksi Streptozotocin Naomi Anryani Tambunan; Stephani Stephani; Muhammad Chairul; Sri Wahyuni Nasution
Jurnal Ners Vol. 10 No. 4 (2026): OKTOBER 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i4.62747

Abstract

Diabetes melitus merupakan penyakit metabolik kronis dengan hiperglikemia yang menghambat penyembuhan luka dan regenerasi folikel rambut melalui stres oksidatif serta pelepasan sitokin proinflamasi. Daun mangkokan (Nothopanax scutellarium) kaya flavonoid, terutama kuersetin, yang berpotensi mempercepat penyembuhan luka dan merangsang folikel rambut. Penelitian ini bertujuan menganalisis pengaruh krim nanoemulsi ekstrak daun mangkokan terhadap penyembuhan luka sayat, pertumbuhan rambut, dan kadar glukosa darah tikus Wistar jantan yang diinduksi streptozotocin (STZ). Penelitian true experimental dengan rancangan pre-test post-test group design menggunakan 25 tikus Wistar jantan yang dibagi acak menjadi 5 kelompok (n=5): Normal (tanpa STZ + luka sayat), Kontrol Negatif (STZ + luka + basis krim), Kontrol Positif (STZ + luka + minoksidil 2%), Perlakuan I (STZ + luka + krim nanoemulsi 10%), dan Perlakuan II (STZ + luka + krim nanoemulsi 20%). Karakterisasi metabolit sekunder dilakukan dengan uji fitokimia kualitatif. Parameter klinis (glukosa darah, panjang luka, panjang rambut) diamati pada hari ke-1, 7, dan 14. Uji fitokimia mengonfirmasi kandungan flavonoid, saponin, tanin, alkaloid, steroid, dan glikosida. Pada hari ke-14, Perlakuan II (20%) menunjukkan penyembuhan luka 95,7%, setara dengan Normal (95,9%) dan Kontrol Positif (94,3%) (p > 0,05). Pertumbuhan rambut Perlakuan II mencapai 21,66 mm, signifikan lebih tinggi daripada Kontrol Negatif (6,62 mm; p = 0,000) dan tidak berbeda signifikan dengan Kontrol Positif (22,00 mm; p = 0,492). Perlakuan II juga menurunkan kadar glukosa darah menjadi 209,4 mg/dL pada hari ke-14. Simpulan, krim nanoemulsi ekstrak daun mangkokan 20% paling efektif mendukung penutupan luka dan regenerasi folikel rambut pada diabetes melitus melalui mekanisme multitarget bioaktif. Temuan ini mendukung pengembangan sediaan topikal berbasis nanoemulsi dari bahan alam sebagai terapi adjuvan untuk penyembuhan luka dan gangguan pertumbuhan rambut pada diabetes, meskipun masih memerlukan uji klinis lanjutan.
Co-Authors Boyke Marthin Simbolon Naomi Anryani Tambunan Stephani Stephani Thoriq Akrom