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The Marine Organisms as Potential Sources of Inhibits ACE on Hypertension Patient Alma Dyah Perwita; Adam Trojan Alisyahbana; Adinda Ilsa Maulida; Alfia Mawaddah; Ali Ramzi; Legis Ocktaviana Saputri
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i1.6162

Abstract

Abstract: Hypertension is a condition of chronic high blood pressure in the systemic arteries which is a major risk factor for cardiovascular disease, kidney disorders, and death. There are two types of hypertension, the primary hypertension is thought to be caused by hereditary factors, age, gender, race, and an unhealthy lifestyle. Secondary hypertension is caused by an obvious cause. The prevalence of hypertension in Indonesia is quite high with the highest incidence rate in South Kalimantan (44,1%) and the lowest in Papua (22,2%). The pathophysiology of hypertension involves the enzyme Angiotensin Converting Enzyme (ACE) which plays a role in regulating blood pressure. The process of converting Angiotensinogen to Angiotensin I, then Angiotensin II by ACE can cause vasoconstriction and fluid retention, which contribute to hypertension. The changes in circulation and blood vessel structure have played a role in the risk of hypertension complications, including stroke. The marine organisms such as fish, shellfish, cephalopods, seaweed, and algae contain peptides with antihypertensive, anticoagulant, antithrombotic, and hypercholesterolemic activities. For example, hydrolyzate of the jellyfish, Rhopilema esculentum can inhibit ACE with a high level of effectiveness. The current hypertension treatment often uses synthetic drugs such as ACE inhibitors and Angiotensin Receptor Blockers (ARBs), but these have undesirable side effects. Therefore, bioactive peptides from marine organisms can be an efficient and safe natural alternative. The research on protein hydrolysates from various sources has found ACE inhibitory activity and several peptides such as Trp-Pro-Met-Gly-Phe (WPMGF) and APP, KPLL, and VYPFPGPIPNSLPQNIPP were identified to have strong ACE inhibitory activity. These findings indicate the potential use of bioactive peptides from marine organisms as a natural alternative for the treatment and prevention of hypertension.
Dinamika Psikologis Pelaku Kekerasan Seksual pada Anak Kayla, Baiq Ghassani; Ali Ramzi; Febbi Anggy; Herodya L Fesmia; Pujiarrohman
Lombok Medical Journal Vol. 2 No. 3 (2023): Lombok Medical Journal Volume 2 Nomor 3
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i2.2774

Abstract

Nowadays cases of sexual violence against children are rife in Indonesia. Cases of sexual violence increase over time. The perpetrators of sexual violence are not only strangers who are not known to the victim, but also the closest people to the victim, such as fathers, uncles, or grandfathers. Ironically, perpetrators of sexual violence in children today are not only carried out by adults, but also carried out by children. The types of perpetrators of sexual violence have also varied greatly, such as perpetrators of rape to perpetrators of internet sexual violence who distribute pornographic content. There are several psychological factors that underlie the perpetrators of sexual violence, such as lack of parental attention, lack of education about intimate organs, to easy access to pornographic photos or films on the internet. There are two factors that cause a person to become a perpetrator of sexual violence, first is historical factors, such as a history of past trauma and second is psychological factors, such as lack of interpersonal communication. Perpetrators of sexual violence in children must get a treatment to overcome the problems experienced. This handling must be carried out by all groups, both from the family, community, and government. Therefore, this article will discuss the psychological dynamics of perpetrators of sexual violence in children, which includes the types of perpetrators of sexual violence, the pathophysiology of psychological dynamics of perpetrators, and efforts to handle perpetrators of sexual violence.
Diagnosis dan Tatalaksana Postherpetic Neuralgia Ali Ramzi; Firza, Fatimah
Lombok Medical Journal Vol. 4 No. 3 (2025): Lombok Medical Journal
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v4i3.7505

Abstract

Postherpetic Neuralgia (PHN) is a chronic pain condition that occurs after the resolution of Herpes zoster, significantly affecting patients’ quality of life. PHN is characterized by spontaneous pain, hyperalgesia, allodynia, and paresthesia. Major risk factors include advanced age, severity of rash, and ophthalmic involvement. The pathophysiology involves reactivation of the varicella-zoster virus (VZV), leading to nerve inflammation and peripheral sensitization. Management of PHN includes analgesics, antiepileptic drugs (pregabalin, gabapentin), antidepressants, and topical therapies such as capsaicin and lidocaine. Prevention can be achieved through zoster vaccination. Combination therapy is often required to optimize treatment outcomes in PHN.    
Dinamika Psikologis Pelaku Kekerasan Seksual pada Anak Kayla, Baiq Ghassani; Ali Ramzi; Febbi Anggy; Herodya L Fesmia; Pujiarrohman
Lombok Medical Journal Vol. 2 No. 3 (2023): Lombok Medical Journal Volume 2 Nomor 3
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i2.2774

Abstract

Nowadays cases of sexual violence against children are rife in Indonesia. Cases of sexual violence increase over time. The perpetrators of sexual violence are not only strangers who are not known to the victim, but also the closest people to the victim, such as fathers, uncles, or grandfathers. Ironically, perpetrators of sexual violence in children today are not only carried out by adults, but also carried out by children. The types of perpetrators of sexual violence have also varied greatly, such as perpetrators of rape to perpetrators of internet sexual violence who distribute pornographic content. There are several psychological factors that underlie the perpetrators of sexual violence, such as lack of parental attention, lack of education about intimate organs, to easy access to pornographic photos or films on the internet. There are two factors that cause a person to become a perpetrator of sexual violence, first is historical factors, such as a history of past trauma and second is psychological factors, such as lack of interpersonal communication. Perpetrators of sexual violence in children must get a treatment to overcome the problems experienced. This handling must be carried out by all groups, both from the family, community, and government. Therefore, this article will discuss the psychological dynamics of perpetrators of sexual violence in children, which includes the types of perpetrators of sexual violence, the pathophysiology of psychological dynamics of perpetrators, and efforts to handle perpetrators of sexual violence.