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Hamid Faqih Umam
General Practitioner, Roemani Muhammadiyah Hospital, Semarang, Indonesia
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Economics, Econometrics & Finance Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology

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A Systematic Review and Meta-Analysis: The Long-Term Effects of Oral N-Acetylcysteine in Chronic Obstructive Pulmonary Disease Nova Nasikhatussoraya; Hamid Faqih Umam; Ainingtyas Marda Rizkani; Hidayat Santoso
Nusantara Science and Technology Proceedings The 4th International Conference on Community Medicine and Medical Sciences
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2024.4404

Abstract

Chronic obstructive pulmonary disease (COPD) is one of the world's most prevalent causes of morbidity and mortality. About 5.6% of Indonesians have COPD. Most COPD patients have mucus hypersecretion and inadequate mucus clearance, leading to airway obstruction. N-acetylcysteine (NAC) is a mucolytic drug with antioxidant and anti-inflammatory effects. Long-term oral NAC use in COPD remains controversial. We searched four databases to analyze the effects of oral NAC in COPD over a minimum six-month treatment. The data was analyzed through Review Manager 5.4. Eight randomized controlled trials, comprising 3.187 patients, were selected for inclusion in the study. NAC had a lower risk of exacerbations (RR 0.78, 95% CI 0.66-0.93; p=0.005), whether at high dose (1200mg/day) or low dose (600mg/day). The risk is higher at the high dose (RR 0.90, p=0.04) than at the low dose (RR 0.70, p=0.0002). NAC did not affect FEV1 (mean difference 4.71, 95% CI -3.20-12.61; p=0.24), and adverse events were the same as with placebo (RR 1.14, 95% CI 0.78-1.67; p=0.51). Long-term oral NAC reduces the risk of COPD exacerbations at any dose and was well tolerated.
A Systematic Review: The Effectiveness of Vitamin D Supplementation on Tuberculosis Spondylitis Aila Mustofa; Hamid Faqih Umam; David Noor Umam
Nusantara Science and Technology Proceedings The 4th International Conference on Community Medicine and Medical Sciences
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2024.4405

Abstract

Introduction: Tuberculosis remains a major global health problem. About 50% of musculoskeletal tuberculosis involves the spine. Vitamin D deficiency is related to a higher risk of tuberculosis infection. Vitamin D has a potential benefit on the immune system during tuberculosis spondylitis. Methods: A systematic review was performed using PRISMA flowchart in five databases to identify articles until July 24th 2024. The risk of bias was evaluated by modified Jadad Scale. Results: Three articles using randomized controlled trials, with a total 162 patients. High-dose vitamin D supplementation (5.000IU and 10.000IU) showed significant efficacy in several indicators. Serum vitamin D levels increased to 38.49 ng/mL. There was an improvement in immune response (TLR2, TLR4) and a decrease in inflammatory markers (TGF-?1, IL-10, IL-17, IL-23, CRP, and ESR). High-dose vitamin D administration was shown to increase overall efficacy (95.65% vs. 80.43%, p<0.05), reduce pain, and improve spinal cord injury grade and activities of daily living. No difference in adverse events was observed in the intervention group. Conclusion: Vitamin D supplementation may improve the efficacy of tuberculosis spondylitis treatment. Further research is needed to determine the recommended dose and duration of supplementation in clinical practice.
The Importance of Blood Pressure Control in End-Stage Renal Disease: A Case Report of Intracranial Hemorrhage Hamid Faqih Umam; Nova Nasikhatussoraya; Shofa Chasani; Durrotul Djannah
Nusantara Science and Technology Proceedings The 4th International Conference on Community Medicine and Medical Sciences
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2024.4407

Abstract

Introduction: End-Stage Renal Disease (ESRD) is a growing global health concern. ESRD often presents with high blood pressure that is unresponsive to medication. Long-standing high blood pressure is the primary cause of intracranial hemorrhage. It is more likely to occur in ESRD patients. Case Illustration: A 69-year-old woman was brought to the emergency room because of unconsciousness four hours earlier. She had a sudden severe headache before that. No history of trauma. Her consciousness was poor (GCS E1M2V1) and her blood pressure was high (213/78 mmHg) in the emergency unit. Head CT revealed intracerebral, intraventricular, and subarachnoid hemorrhages with a total volume of 81 cc and midline shift. The patient had been on dialysis twice a week for six years. She had uncontrolled hypertension said to routinely take antihypertensive drugs independently. Last year's dialysis visits showed high blood pressure, with a mean of 187/72 mmHg (224/112-166/51 mmHg). Given her complex condition, she underwent conservative therapy and died on the third day of treatment. Conclusion: ESRD patients are at high risk of intracranial hemorrhage. It is crucial to closely monitor blood pressure during dialysis visits. ESRD with intracranial hemorrhage has a poor prognosis, emphasizing the importance of preventive care.
Co-Authors Aila Mustofa Ainingtyas Marda Rizkani David Noor Umam Durrotul Djannah Hidayat Santoso Nova Nasikhatussoraya Shofa Chasani