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All Journal Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Jurnal Kedokteran Methodist
Surjit Singh
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other

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Keracunan Organofosfat Annisaul Ula; Surjit Singh
Vitalitas Medis : Jurnal Kesehatan dan Kedokteran Vol. 2 No. 1 (2025): Vitalitas Medis : Jurnal Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/vimed.v2i1.1039

Abstract

Organophosphates are a group of compounds with toxic potential that inhibit cholinesterase, leading to the accumulation of acetylcholine at muscarinic, nicotinic receptors, and the central nervous system, which can result in death. Organophosphates are the most toxic insecticides compared to other types of pesticides and are often responsible for poisoning in humans. The symptoms of organophosphate poisoning vary widely. Each symptom depends largely on persistent acetylcholine stimulation or depression, followed by stimulation of the central and peripheral nervous systems. Early symptoms such as salivation, lacrimation, urination, and diarrhea (SLUD) occur in acute organophosphate poisoning due to stimulation of muscarinic receptors, leading to an increase in acetylcholine levels in the blood, eyes, and smooth muscles. Management of organophosphate poisoning involves stabilizing the patient, decontamination, and administering antidotes such as antimuscarinic agents, oximes, and anticonvulsants. Complications from organophosphate poisoning include respiratory failure, seizures, aspiration pneumonia, and even death. Postmortem examination of organophosphate poisoning may reveal cyanosis on the lips, fingertips, and nails, systemic or pulmonary congestion, dilation of the right heart, dark bluish-red livor mortis that forms more quickly, and a wider distribution of livor mortis due to high carbon dioxide levels.
The Incidence of Pulmonary Tuberculosis in HIV/AIDS Patients at Deli Serdang Regional General Hospital, 2013–2015 Soniya Krishna; Parluhutan Sigian; Surjit Singh
Jurnal Kedokteran Methodist Vol. 17 No. 2 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i2.5371

Abstract

Background: In 2010, the number of TB patients rose to 330,000 and in2012, the number of TB patients is quite sharp, ie 583,000 people. TB isthe number one killer among infectious diseases and ranking third in thelist of top ten diseases in Indonesia which causes about 100,000 deathsannually, or in a day occurred 300 deaths due to TB.Methods: This study is a descriptive and cross sectional study conductedat the Medical Records Regional General Hospital Deli Serdang years2013-2015 total of 49 samples were selected with a total samplingtechnique.Results: Based on the research that has been done, the highest age groupwith pulmonary tuberculosis in people with HIV / AIDS is as much as32.65% of 25-30 years, by sex more dominant male is 79.59%, based onthe most common residence is outside city field as much as 83.67%, thehighest frequency based on the self- employed work is as much as 38.77%,the highest frequency of risk factors based on sex is as much as 71.42%and the highest frequency based on CD4 count is <200 as much as91.83%.Conclusion: Based on this study concluded that the incidence ofpulmonary TB in people with HIV / AIDS are still very high, the highest inthe age group 25-30 years of age and male gender, the dominantoccupation were self-employed, the highest risk factor was sexual relationswith CD4 count <200.
Co-Authors Annisaul Ula Parluhutan Sigian Soniya Krishna