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All Journal The Journal of Experimental Life Sciences (JELS)
Kalimuthu, Senthilkumar
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

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Assessment of Vitamin D Deficiency Prevalence among Type 2 Diabetes Mellitus Patients in a South Indian Tertiary Care Hospital Kalimuthu, Senthilkumar; Philip, Sachu; Elango Nandhini, Natarajan; Baba, Lalamiya Abdul Rahiman; Ravichandran, Shanmugasundaram
The Journal of Experimental Life Science Vol. 14 No. 3 (2024)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2024.014.03.01

Abstract

Vitamin D deficiency has become a global health issue and is associated with the multifactorial clinical manifestations of diabetes. The objective of this study is to analyze vitamin D deficiency in T2DM patients in association with biochemical parameters and thyroid-stimulating hormone (TSH). This study was a cross-sectional study in a tertiary care hospital conducted after the Institutional Ethical Committee (IEC) approval. The available descriptive data of patients, such as age, gender, biochemical parameters, TSH, and glycated hemoglobin (HbA1c), were collected. Vitamin D was measured using the enzyme-linked immunosorbent assay (ELISA) method. The descriptive parameters were statistically analyzed using chi-square analysis. The results comprise 322 T2DM patients, with 187 males and 135 females. Vitamin D status levels were observed to have severe deficiency < 10 ng.mL-1 (23.6%), deficiency >10-20 ng.mL-1 (42.2%), insufficient >20-29 ng.mL-1 (22.7%), and sufficient > 30 ng.mL-1 (11.5%). The male and female patients with vitamin D status were significantly (p<0.001) different between groups. No significant (p = 0.122) association was observed between HbA1c and vitamin D. The high status of vitamin D deficiency with high glycemic levels is associated with poor diabetic control. Therefore, patients require awareness about their vitamin D status; with a proper diet, adequate exposure to sunlight, and exercise can help them improve their health. Keywords: Cholesterol, HbA1c, TSH, Type 2 diabetes mellitus, Vitamin D.
Histopathologic Evaluation of Gastrointestinal Endoscopic Biopsies with Risk Factor Analysis in a Tertiary Care Hospital in South India Lalamiya Abdul Rahiman, Baba; Maruthamuthu , Rajendran; Padipurakkal Haneefa, Shajitha; Kalimuthu, Senthilkumar
The Journal of Experimental Life Science Vol. 15 No. 2 (2025)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2025.015.02.02

Abstract

Gastrointestinal tract (GIT) disorders are a major common problem with morbidity and mortality.  The disorders can cause inflammatory and neoplastic changes in the GIT.  Endoscopy and biopsy, in combination, play a central role in the early diagnosis and management of the disease.  This research study carried out the histopathological evaluation of GIT endoscopic biopsies and risk factor analysis. A total of 171 endoscopic biopsies were examined in this prospective study. The received formalin-fixed tissues were processed for histopathology analysis in the department of pathology through Hematoxylin-Eosin staining, and slides were mounted using Dibutylphthalate Polystyrene Xylene (DPX). Additional sections were stained with periodic acid Schiff (PAS) stain to observe adenocarcinoma. The gastric neoplastic changes incidence among patients with endoscopic biopsies sample was about 9 (5.3%), others diagnosis with Helicobacter Pylori 18 (10.5%), congestion 8 (4.7%), candida 8 (4.7%), and normal or non-neoplastic 128 (74.9%). The diagnosed malignancies were adenocarcinoma and squamous cell carcinoma. The diagnosed histopathology of the endoscopy biopsy samples was found to be mostly chronic gastritis and also neoplastic changes. Therefore, endoscopy with a biopsy of histopathology can be useful in diagnosing GIT disease. Further studies required with more cases with clinical data could be helpful for this research.  
Co-Authors Baba, Lalamiya Abdul Rahiman Elango Nandhini, Natarajan Lalamiya Abdul Rahiman, Baba Maruthamuthu , Rajendran Padipurakkal Haneefa, Shajitha Philip, Sachu Ravichandran, Shanmugasundaram