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All Journal Media Kedokteran Hewan
Usman, Abdulrauf Adekunle
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Medicine & Pharmacology Veterinary

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Case of Metastatic Canine Transmissible Venereal Tumor in a Dog: Clinical and Cytological Evaluation Olaifa, Olanrewaju Samuel; Usman, Abdulrauf Adekunle; Adebiyi, Taiwo Kemi; Ogunro, Bamidele Nyemike; Osereime, Adah; Antia, Richard Edem; Ajibade, Favour Akinfemi; Adeshubomi, Ojuolape Adeyemi; Soneye, Toluwalase Oluwatimilehin
Media Kedokteran Hewan Vol. 36 No. 1 (2025): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v36i1.2025.77-87

Abstract

Canine transmissible venereal tumor (TVT) is a naturally occurring, transmissible neoplasm primarily affecting the genitalia in dogs. Though generally benign, it can rarely metastasize to other body parts. This report describes a rare case of metastatic TVT in a 2-year-old female Boerboel, presenting with a large, ulcerated vulvar mass and metastases to the popliteal lymph node and mammary glands. Clinical findings included progressive mass growth, emaciation, and systemic symptoms. Hematological tests revealed non-regenerative anemia and elevated white blood cell count, while cytological examination identified neoplastic round cells with high nucleus-to-cytoplasm ratios and mitotic figures. The dog was treated with vincristine chemotherapy, metronidazole, vitamin C, and a diet supplemented with crude sap extract of Telfairia occidentalis at 120 mg/kg once daily. Significant tumor regression and clinical improvement were observed after four weeks, although persistent anemia and borderline hypoproteinemia were noted. By the fifth week, the mass had notably reduced, and the dog's condition continued to improve, though some hemorrhage remained. This case highlights the rare occurrence of metastatic TVT and underscores the effectiveness of vincristine in treatment, emphasizing the need for prompt diagnosis and management despite its generally low metastatic rate.
Metastatic Calcification Associated with Chronic Kidney Disease in a 5-Year-Old Boerboel Dog Shakiru, Habeeb; OLA, Olawale Olawumi; Olaifa, Olanrewaju Samuel; Tijani, Monsuru Oladunjoye; Jarikre, Theophilus Aghogho; Usman, Abdulrauf Adekunle; Ajani, Tola Felicia Orotusin; Adejumobi, Olumuyiwa Abiola; Omobowale , Temidayo Olutayo
Media Kedokteran Hewan Vol. 37 No. 1 (2026): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v37i1.2026.62-72

Abstract

Pathologic mineralization refers to the abnormal deposition of calcium salts in tissues. In dogs, metastatic calcification is an uncommon but serious complication of chronic kidney disease (CKD), resulting from disturbances in calcium/phosphorus metabolism or renal damage by infectious agents. A 5-year-old female Boerboel was presented because of one week of anorexia. Clinical assessment revealed severe emaciation, dehydration, azotemia, hyperphosphatemia, and concurrent ehrlichiosis. Despite oxytetracycline and doxycycline therapy for two days, the dog died. Necropsy and histopathological examination were performed. Grossly, there was extensive mineralization of the diaphragm, intercostal muscles, pleura, pharynx, and great vessels. Histopathology showed tubular epithelial degeneration, protein casts, tubular ectasia, and interstitial fibrosis, consistent with advanced CKD. Laboratory findings of azotemia, hyperphosphatemia, hypoalbuminemia, and hypercalcemia supported renal failure as the underlying process driving the soft tissue mineralization.  Extra-renal lesions included hepatocellular atrophy with vacuolar change, Kupffer cell hyperplasia, bronchointerstitial pneumonia with pulmonary edema, and hemorrhagic follicular cystitis with mononuclear infiltration. The combined gross and histopathological findings demonstrate how renal failure-induced mineral imbalance can drive widespread soft tissue mineralization. Veterinary clinicians must monitor calcium/phosphorus status to anticipate life-threatening sequelae.
Oxidative Stress Assessment in Serum and Bronchoalveolar Lavage Fluid (BALF) of Normal and Pneumonic Sheep Ajayi, John Olurotimi; Jarikre, Theophilus Aghogho; Usman, Abdulrauf Adekunle; Emikpe, Benjamin Obukuwho; Taiwo, Victor Olusegun
Media Kedokteran Hewan Vol. 37 No. 2 (2026): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v37i2.2026.214-223

Abstract

Oxidative stress plays a critical role in the pathogenesis of respiratory diseases in small ruminants; however, a comprehensive assessment comparing systemic and local pulmonary oxidative status in naturally infected Nigerian indigenous sheep is lacking. This study evaluated oxidative parameters in serum and bronchoalveolar lavage fluid (BALF) from 210 sheep, including healthy controls and animals with naturally occurring pneumonia. Samples were analyzed for total protein, enzymatic antioxidants (glutathione peroxidase, glutathione transferase, superoxide dismutase), non-enzymatic antioxidants (reduced glutathione, vitamin C), and oxidative stress markers (myeloperoxidase, malondialdehyde, hydrogen peroxide, and nitric oxide). In pneumonic sheep, serum and BALF levels of glutathione peroxide, glutathione transferase, and superoxide dismutase were significantly reduced, whereas levels of myeloperoxidase, hydrogen peroxide, and nitric oxide were markedly increased. Malondialdehyde showed mild elevation. The most significant oxidative disturbances were observed in bronchopneumonia, bronchointerstitial pneumonia, and granulomatous pneumonia. These results demonstrate a pronounced oxidative imbalance in both the systemic and pulmonary compartments of sheep with pneumonia. Therefore, this study provides novel evidence supporting the integration of antioxidant therapy and targeted nutritional management into standard care protocols to mitigate oxidative damage and improve outcomes in pneumonic sheep.
Co-Authors Adebiyi, Taiwo Kemi Adejumobi, Olumuyiwa Abiola Adeshubomi, Ojuolape Adeyemi Ajani, Tola Felicia Orotusin Ajayi, John Olurotimi Ajibade, Favour Akinfemi Antia, Richard Edem Emikpe, Benjamin Obukuwho Jarikre, Theophilus Aghogho Ogunro, Bamidele Nyemike Ola, Olawale Olawumi Olaifa, Olanrewaju Samuel Omobowale , Temidayo Olutayo Osereime, Adah Shakiru, Habeeb Soneye, Toluwalase Oluwatimilehin Taiwo, Victor Olusegun Tijani, Monsuru Oladunjoye